Session 2G: C1q-TNF Related Protein 9 Levels Are Increased In Systemic Sclerosis and Correlates with Interstitial Lung Disease
Session Number
Session 2G: 4th Presentation
Advisor(s)
John Varga, Northwestern University
Location
Room A117
Start Date
28-4-2017 10:00 AM
End Date
28-4-2017 11:15 AM
Abstract
Systemic Sclerosis (SSc) is an autoimmune rheumatic disease with the highest mortality rate amongst autoimmune connective tissue diseases. The disease causes symptoms such as inflammation within the dermis and other organs. Adipocytes are fat cells which aid in the progression of SSc by regulating the immune system and metabolic pathways. C1q/TNF-Related Protein 3 (CTRP3) and C1q/TNF-Related Protein 9 (CTRP9) are adipokines that act as anti-inflammatory proteins. Currently, there are no biomarkers which are used to diagnose the progression of SSc, but due to the anti-inflammatory properties of CTRP3 and CTRP9, they are potential biomarkers to the progression of SSc. This study indicates that patients with SSc and lung fibrosis had elevated CTRP9 levels compared to healthy individuals. CTRP9 could potentially be used as a diagnostic biomarker to indicate whether a patient has SSc or interstitial lung disease.
Session 2G: C1q-TNF Related Protein 9 Levels Are Increased In Systemic Sclerosis and Correlates with Interstitial Lung Disease
Room A117
Systemic Sclerosis (SSc) is an autoimmune rheumatic disease with the highest mortality rate amongst autoimmune connective tissue diseases. The disease causes symptoms such as inflammation within the dermis and other organs. Adipocytes are fat cells which aid in the progression of SSc by regulating the immune system and metabolic pathways. C1q/TNF-Related Protein 3 (CTRP3) and C1q/TNF-Related Protein 9 (CTRP9) are adipokines that act as anti-inflammatory proteins. Currently, there are no biomarkers which are used to diagnose the progression of SSc, but due to the anti-inflammatory properties of CTRP3 and CTRP9, they are potential biomarkers to the progression of SSc. This study indicates that patients with SSc and lung fibrosis had elevated CTRP9 levels compared to healthy individuals. CTRP9 could potentially be used as a diagnostic biomarker to indicate whether a patient has SSc or interstitial lung disease.
Comments
Additional team members: Dr. Roberta Marangoni and Dr. Benjamin Korman