Session 3F: Identification of a Clinical Score to Estimate the Risk for the Development of Incident Resistant Hypertension

Session Number

Session 3F: 1st Presentation

Advisor(s)

John M. Flack, Southern Illinois University

Location

Room A115

Start Date

28-4-2017 1:15 PM

End Date

28-4-2017 2:30 PM

Abstract

Uncontrolled resistance hypertension referred to patients taking three or more antihypertensive medications with at least one being a diuretic and BP above threshold values (140/90 mmHg). The purpose of this study was to predict an empirical baseline variable that discriminated hypertensive patients who did or did not eventually develop resistant hypertension over a 150 day period using receiver operating characteristics (ROC) curves. The retrospective cohort study included de-identified medical records of 134 hypertensive patients followed-up in an urban clinic between October 1998 and May 2010. The patients all did impedance cardiography (ICG), a non-invasive hemodynamic procedure to determine exposure systemic vascular resistance (SVR). The covariates were diabetes, prediabetes, albuminuria or glomerular filtration rate. The associations were binarily classified on a receiver operating characteristic (ROC) curve. The area under the ROC curve (AUC) was calculated to test the accuracy of the predictor model and if the empirical cut-off points could be used in a clinical setting. Patients were mostly African Americans, females, diabetics, all with a mean baseline SV and extremely high odds. Results from this study will enable clinicians to assess a binary statement to their patients on whether they will or will not develop resistance hypertension within a 150 day follow-up period.

Comments

Additional team members: Dr. Albert Botchway

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Apr 28th, 1:15 PM Apr 28th, 2:30 PM

Session 3F: Identification of a Clinical Score to Estimate the Risk for the Development of Incident Resistant Hypertension

Room A115

Uncontrolled resistance hypertension referred to patients taking three or more antihypertensive medications with at least one being a diuretic and BP above threshold values (140/90 mmHg). The purpose of this study was to predict an empirical baseline variable that discriminated hypertensive patients who did or did not eventually develop resistant hypertension over a 150 day period using receiver operating characteristics (ROC) curves. The retrospective cohort study included de-identified medical records of 134 hypertensive patients followed-up in an urban clinic between October 1998 and May 2010. The patients all did impedance cardiography (ICG), a non-invasive hemodynamic procedure to determine exposure systemic vascular resistance (SVR). The covariates were diabetes, prediabetes, albuminuria or glomerular filtration rate. The associations were binarily classified on a receiver operating characteristic (ROC) curve. The area under the ROC curve (AUC) was calculated to test the accuracy of the predictor model and if the empirical cut-off points could be used in a clinical setting. Patients were mostly African Americans, females, diabetics, all with a mean baseline SV and extremely high odds. Results from this study will enable clinicians to assess a binary statement to their patients on whether they will or will not develop resistance hypertension within a 150 day follow-up period.