Session 2D: Molecular Cloning and Characterization of Short RNA Sequences That May Interrupt Osteogenic Differentiation of Mesenchymal Stem Cells
Session Number
Session 2D: 4th Presentation
Advisor(s)
Tong-Chuan He, University of Chicago
Location
Room A155
Start Date
28-4-2017 10:00 AM
End Date
28-4-2017 11:15 AM
Abstract
Osteosarcoma can be regarded as a differentiation disease that is caused by genetic and epigenetic disruptions of osteoblast terminal differentiation. Using an innovative approach of genome-wide functional screening, we have recently uncovered that forced expression of certain short RNA (19-base) may disrupt BMP9-induced bone formation from MSCs. These short RNA are designated as Disruptors of Osteogenesis induced by BMP9 (or DONs). This study determines that the candidate DONs can effectively disrupt osteogenic differentiation and bone formation from MSCs, rendering MSCs bone tumor-like phenotype in a mouse model.
Session 2D: Molecular Cloning and Characterization of Short RNA Sequences That May Interrupt Osteogenic Differentiation of Mesenchymal Stem Cells
Room A155
Osteosarcoma can be regarded as a differentiation disease that is caused by genetic and epigenetic disruptions of osteoblast terminal differentiation. Using an innovative approach of genome-wide functional screening, we have recently uncovered that forced expression of certain short RNA (19-base) may disrupt BMP9-induced bone formation from MSCs. These short RNA are designated as Disruptors of Osteogenesis induced by BMP9 (or DONs). This study determines that the candidate DONs can effectively disrupt osteogenic differentiation and bone formation from MSCs, rendering MSCs bone tumor-like phenotype in a mouse model.
Comments
Additional team members: Dr. Junyi Liao