Event Title

Session 1B: The Effects of Phenol on Locomotor Behavior and Aging on Drosophila melanogaster

Session Number

Session 1B: 1st Presentation

Advisor(s)

Dr. Vandana Chinwalla, IMSA

Location

Lecture Hall

Start Date

26-4-2018 9:40 AM

End Date

26-4-2018 10:25 AM

Abstract

In today’s world, there is a constant threat of environmental pollutants, which negatively affect the daily lives of humans. One of these known pollutants is phenol, found commonly in low concentrations in consumer products such as mouthwash, lotions, and ointments. Phenol has been found to accelerate senescence and decrease lifespan when introduced during early development. This study utilized Drosophila melanogaster, wild-type fruit fly, as a model organism to assess the effects of 0.1% phenol relative to a control group raised on water media. Through assays such as negative geotaxis, and longevity, the instinctual locomotor behavior and lifespan of fruit flies were assessed as they aged. Running a mixed- effects model analysis with treatment and sex as the fixed effects and weeks as the random effect confirmed that there was a significant difference between flies raised on the phenol medium versus the control group (p< 0.05). Further research will be performed to counteract the aforementioned negative effects through the introduction of antioxidants or anti-inflammatory substances, such as cranberry extract or curcumin, into the diet of the phenol-exposed flies.

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Apr 26th, 9:40 AM Apr 26th, 10:25 AM

Session 1B: The Effects of Phenol on Locomotor Behavior and Aging on Drosophila melanogaster

Lecture Hall

In today’s world, there is a constant threat of environmental pollutants, which negatively affect the daily lives of humans. One of these known pollutants is phenol, found commonly in low concentrations in consumer products such as mouthwash, lotions, and ointments. Phenol has been found to accelerate senescence and decrease lifespan when introduced during early development. This study utilized Drosophila melanogaster, wild-type fruit fly, as a model organism to assess the effects of 0.1% phenol relative to a control group raised on water media. Through assays such as negative geotaxis, and longevity, the instinctual locomotor behavior and lifespan of fruit flies were assessed as they aged. Running a mixed- effects model analysis with treatment and sex as the fixed effects and weeks as the random effect confirmed that there was a significant difference between flies raised on the phenol medium versus the control group (p< 0.05). Further research will be performed to counteract the aforementioned negative effects through the introduction of antioxidants or anti-inflammatory substances, such as cranberry extract or curcumin, into the diet of the phenol-exposed flies.