TNF: The Key To Preventing Type 1 Diabetes
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Location
Room B125
Start Date
26-4-2019 9:45 AM
End Date
26-4-2019 10:00 AM
Abstract
Insulitis is caused by a pathway of inflammatory steps lead predominantly by Tumor Necrosis Factor (TNF), Interferon Gamma (INF-y), and Interleukin 1 beta (IL-1b). Within Type 1 diabetes, an inflammatory disease, these same cytokines have been linked to the progression of this condition both within the immune system, and at a cellular level. It has been determined that by neutralizing TNF, INF-y, and IL-1b, one can inhibit the development of Type 1 diabetes.By using SeeSAR to modify small-molecule inhibitors found in PDB, two potential archetypes of TNF-inhibitors have been found, both of which are drastically smaller than the monoclonal antibody competitors on the market, indicating potential for cost-effective treatment of rheumatoid arthritis and insulitis.
TNF: The Key To Preventing Type 1 Diabetes
Room B125
Insulitis is caused by a pathway of inflammatory steps lead predominantly by Tumor Necrosis Factor (TNF), Interferon Gamma (INF-y), and Interleukin 1 beta (IL-1b). Within Type 1 diabetes, an inflammatory disease, these same cytokines have been linked to the progression of this condition both within the immune system, and at a cellular level. It has been determined that by neutralizing TNF, INF-y, and IL-1b, one can inhibit the development of Type 1 diabetes.By using SeeSAR to modify small-molecule inhibitors found in PDB, two potential archetypes of TNF-inhibitors have been found, both of which are drastically smaller than the monoclonal antibody competitors on the market, indicating potential for cost-effective treatment of rheumatoid arthritis and insulitis.