Peri-Implant Osteolysis Effects on Local and Remote Tissues
Advisor(s)
Meghan Moran, Rush University Medical Center
Location
Room B115
Start Date
26-4-2019 10:05 AM
End Date
26-4-2019 10:20 AM
Abstract
Orthopedic implant loosening is one of the main causes for the high number of revision surgeries after primary hip and knee joint replacement surgery (arthroplasty). Implant loosening is often the result of implant wear particles that trigger peri-implant bone loss (osteolysis). There has been growing evidence suggesting that changes in the gut microbiome can induce changes in bone. The gut microbiome consists of a variety of different microorganisms. This study aims to determine if the progression of peri-implant osteolysis due to implant wear particles induces changes in the gut, specifically in the tissue and composition using in-vivo rat models. Rats underwent implant surgery with titanium implant placed in the intramedullary canal of the femur. Study groups included control animals, animals that received knee injections of either a vehicle/control treatment or lipopolysaccharide (LPS) doped polyethylene (PE) particles, which are wear particles to induce peri-implant bone loss. Histological analyses were completed on local tissues at the knee joint to identify particle presence and changes in cell type and activity as well as remote tissues, specifically in the intestine (proximal and distal colon). The goal of this study is to identify a novel mechanism for intervention of failed orthopedic implants.
Peri-Implant Osteolysis Effects on Local and Remote Tissues
Room B115
Orthopedic implant loosening is one of the main causes for the high number of revision surgeries after primary hip and knee joint replacement surgery (arthroplasty). Implant loosening is often the result of implant wear particles that trigger peri-implant bone loss (osteolysis). There has been growing evidence suggesting that changes in the gut microbiome can induce changes in bone. The gut microbiome consists of a variety of different microorganisms. This study aims to determine if the progression of peri-implant osteolysis due to implant wear particles induces changes in the gut, specifically in the tissue and composition using in-vivo rat models. Rats underwent implant surgery with titanium implant placed in the intramedullary canal of the femur. Study groups included control animals, animals that received knee injections of either a vehicle/control treatment or lipopolysaccharide (LPS) doped polyethylene (PE) particles, which are wear particles to induce peri-implant bone loss. Histological analyses were completed on local tissues at the knee joint to identify particle presence and changes in cell type and activity as well as remote tissues, specifically in the intestine (proximal and distal colon). The goal of this study is to identify a novel mechanism for intervention of failed orthopedic implants.