Event Title

Effects of ERG Gene Knockdown in Lung Cancer Cells on Endothelium Permeability

Advisor(s)

Dr. Dolly Mehta, the University of Illinois at Chicago College of Pharmacy

Location

Room B108-2

Start Date

26-4-2019 10:45 AM

End Date

26-4-2019 11:00 AM

Abstract

Compelling evidence suggests endothelium permeability comprises vascular architecture affecting a body’s angiogenesis and tumorigenesis. One of the key factors of endothelium permeability is the ERG gene which is located in the nuclei of endothelial cells. The ERG gene is classified as a proto-oncogene which means that through excessive mutation it can code for factors causing cancer. Through QPCR and RNA extraction from lung samples, we studied ERG gene knockdown and how the endothelium permeability affected basic functions of the cell along with vascular permeability. By seeing the suppression of certain protein functions, we can analyze the role of ERG in lung tissue. This study furthers the understanding of ERG gene knockdown and its correlation with tumorigenesis and by learning more about ERG’s function along with the inhibition of lung cancer cells.

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Apr 26th, 10:45 AM Apr 26th, 11:00 AM

Effects of ERG Gene Knockdown in Lung Cancer Cells on Endothelium Permeability

Room B108-2

Compelling evidence suggests endothelium permeability comprises vascular architecture affecting a body’s angiogenesis and tumorigenesis. One of the key factors of endothelium permeability is the ERG gene which is located in the nuclei of endothelial cells. The ERG gene is classified as a proto-oncogene which means that through excessive mutation it can code for factors causing cancer. Through QPCR and RNA extraction from lung samples, we studied ERG gene knockdown and how the endothelium permeability affected basic functions of the cell along with vascular permeability. By seeing the suppression of certain protein functions, we can analyze the role of ERG in lung tissue. This study furthers the understanding of ERG gene knockdown and its correlation with tumorigenesis and by learning more about ERG’s function along with the inhibition of lung cancer cells.