Advisor(s)

Bethany Perez-White, Northwestern University Feinberg School of Medicine

Location

Room Café

Start Date

26-4-2019 1:40 PM

End Date

26-4-2019 2:05 PM

Abstract

Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction catastrophe. In EphA2-deficient (shEphA2) 3D RHS we show significant loss (>75%, P

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Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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Apr 26th, 1:40 PM Apr 26th, 2:05 PM

Loss of EphA2 inhibits GATA-3 transcriptional function leading to a terminal differentiation defect

Room Café

Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction catastrophe. In EphA2-deficient (shEphA2) 3D RHS we show significant loss (>75%, P

 

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