Event Title

Preliminary Research on TLR4 mediated signaling, Immunoglobulin Superfamily Protein Family (IgSF), and Killer-cell immunoglobulin-like receptors (KIRs

Session Number

Project ID: MEDH 15

Advisor(s)

Dr. Bhagwati Joshi; University of Illinois at Chicago, College of Pharmacy

Dr. Dolly Mehta; University of Illinois at Chicago, College of Pharmacy

Discipline

Medical and Health Sciences

Start Date

22-4-2020 9:10 AM

End Date

22-4-2020 9:25 AM

Abstract

Compelling evidence suggests that Gram-negative bacteria is primarily mediated by a recognition molecule, Toll-like receptor 4, also known as TLR4. TLR4 recognizes lipopolysaccharide (LPS) and begins a series of intracellular NF-kappaB-associated signaling events. Through preliminary research analyzing various key components in upstream and downstream signaling, we examined various cellular interactions and researched mutations. Furthermore, we examined examples of Immunoglobulin Superfamily Protein Family (IgSF) and Killer-cell immunoglobulin-like receptors (KIRs) to look at how the proteins and genes have the potential to assist the inquiry of TLR4 mediated signaling. By seeing the various regulators and transmembrane proteins, we are able to refine the direction of our research to increase our knowledge of the pathway’s functionality. This study aims to further our preliminary understanding of various pathways involving IgSF and KIRS and specifically, TLR4 mediated signaling.

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Apr 22nd, 9:10 AM Apr 22nd, 9:25 AM

Preliminary Research on TLR4 mediated signaling, Immunoglobulin Superfamily Protein Family (IgSF), and Killer-cell immunoglobulin-like receptors (KIRs

Compelling evidence suggests that Gram-negative bacteria is primarily mediated by a recognition molecule, Toll-like receptor 4, also known as TLR4. TLR4 recognizes lipopolysaccharide (LPS) and begins a series of intracellular NF-kappaB-associated signaling events. Through preliminary research analyzing various key components in upstream and downstream signaling, we examined various cellular interactions and researched mutations. Furthermore, we examined examples of Immunoglobulin Superfamily Protein Family (IgSF) and Killer-cell immunoglobulin-like receptors (KIRs) to look at how the proteins and genes have the potential to assist the inquiry of TLR4 mediated signaling. By seeing the various regulators and transmembrane proteins, we are able to refine the direction of our research to increase our knowledge of the pathway’s functionality. This study aims to further our preliminary understanding of various pathways involving IgSF and KIRS and specifically, TLR4 mediated signaling.