Event Title

Covid Moonshot: Fragment Screening for SARS-CoV2 Main Protease (mPro)

Advisor(s)

Dr. John Thurmond; Illinois Mathematics and Science Academy

Discipline

Chemistry

Start Date

21-4-2021 8:50 AM

End Date

21-4-2021 9:05 AM

Abstract

The viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is particularly active early in the course of the disease, giving great value to antiviral therapeutics which hold the potential to halt further progression to the hyperinflammatory state and later stages of disease. Because antiviral therapy is currently high in the interests of the people, an internationally crowdsourced effort aptly named the Covid Moonshot Project was created to accelerate the development of an antiviral drug. To aid in this initiative, numerous new compounds were designed and tested through various dynamic visualization programs and property-predicting applications. The top eight compounds designed were submitted to the Covid Moonshot labs around the world for further development.

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Apr 21st, 8:50 AM Apr 21st, 9:05 AM

Covid Moonshot: Fragment Screening for SARS-CoV2 Main Protease (mPro)

The viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is particularly active early in the course of the disease, giving great value to antiviral therapeutics which hold the potential to halt further progression to the hyperinflammatory state and later stages of disease. Because antiviral therapy is currently high in the interests of the people, an internationally crowdsourced effort aptly named the Covid Moonshot Project was created to accelerate the development of an antiviral drug. To aid in this initiative, numerous new compounds were designed and tested through various dynamic visualization programs and property-predicting applications. The top eight compounds designed were submitted to the Covid Moonshot labs around the world for further development.