Event Title

Synthesis of 2-aminothiazole derivatives as potential treatments of Mycetoma

Session Number

Project ID: MEDH 31

Advisor(s)

Dr. John Thurmond, Illinois Mathematics and Science Academy

Discipline

Medical and Health Sciences

Start Date

20-4-2022 9:30 AM

End Date

20-4-2022 9:45 AM

Abstract

Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in the limbs, causing deformity and physical disability. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. In order to combat this disease, an open-source project has been opened in order to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.

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Apr 20th, 9:30 AM Apr 20th, 9:45 AM

Synthesis of 2-aminothiazole derivatives as potential treatments of Mycetoma

Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in the limbs, causing deformity and physical disability. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. In order to combat this disease, an open-source project has been opened in order to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.