Synthesis of 2-aminothiazole derivatives as potential treatments of Mycetoma
Session Number
Project ID: MEDH 31
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
20-4-2022 9:30 AM
End Date
20-4-2022 9:45 AM
Abstract
Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in the limbs, causing deformity and physical disability. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. In order to combat this disease, an open-source project has been opened in order to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.
Synthesis of 2-aminothiazole derivatives as potential treatments of Mycetoma
Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in the limbs, causing deformity and physical disability. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. In order to combat this disease, an open-source project has been opened in order to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.