The cost variations of tiopronin and the synthesis behind it
Session Number
Project ID: MEDH 33
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
20-4-2022 10:25 AM
End Date
20-4-2022 10:40 AM
Abstract
Cystinuria is a medical condition in which stones that are composed of an amino acid called Cysteine are found strictly in the bladder, kidney, and ureter. Said condition is controlled through a medication documented as tiopronin; however after Thiola, the most common anaccessible brand, raised prices by 2900%, it became virtually impossible to afford. This study works through the synthesis of tiopronin and the costs associated with the synthesis in our lab. The process includes the combination of 2-chloropropionic acid and thionyl chloride forming ⍺-chlorpromazine which is then involved in a coupling reaction with glycine and sodium carbonate to form ⍺-chloropropionylglycine. This product was then combined with sodium sulfide nonahydrate, sulfur, and sodium hydroxide to form tiopronin. Results and cost analysis will be described.
The cost variations of tiopronin and the synthesis behind it
Cystinuria is a medical condition in which stones that are composed of an amino acid called Cysteine are found strictly in the bladder, kidney, and ureter. Said condition is controlled through a medication documented as tiopronin; however after Thiola, the most common anaccessible brand, raised prices by 2900%, it became virtually impossible to afford. This study works through the synthesis of tiopronin and the costs associated with the synthesis in our lab. The process includes the combination of 2-chloropropionic acid and thionyl chloride forming ⍺-chlorpromazine which is then involved in a coupling reaction with glycine and sodium carbonate to form ⍺-chloropropionylglycine. This product was then combined with sodium sulfide nonahydrate, sulfur, and sodium hydroxide to form tiopronin. Results and cost analysis will be described.