Event Title

The cost variations of tiopronin and the synthesis behind it

Session Number

Project ID: MEDH 33

Advisor(s)

Dr. John Thurmond, Illinois Mathematics and Science Academy

Discipline

Medical and Health Sciences

Start Date

20-4-2022 10:25 AM

End Date

20-4-2022 10:40 AM

Abstract

Cystinuria is a medical condition in which stones that are composed of an amino acid called Cysteine are found strictly in the bladder, kidney, and ureter. Said condition is controlled through a medication documented as tiopronin; however after Thiola, the most common anaccessible brand, raised prices by 2900%, it became virtually impossible to afford. This study works through the synthesis of tiopronin and the costs associated with the synthesis in our lab. The process includes the combination of 2-chloropropionic acid and thionyl chloride forming ⍺-chlorpromazine which is then involved in a coupling reaction with glycine and sodium carbonate to form ⍺-chloropropionylglycine. This product was then combined with sodium sulfide nonahydrate, sulfur, and sodium hydroxide to form tiopronin. Results and cost analysis will be described.

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Apr 20th, 10:25 AM Apr 20th, 10:40 AM

The cost variations of tiopronin and the synthesis behind it

Cystinuria is a medical condition in which stones that are composed of an amino acid called Cysteine are found strictly in the bladder, kidney, and ureter. Said condition is controlled through a medication documented as tiopronin; however after Thiola, the most common anaccessible brand, raised prices by 2900%, it became virtually impossible to afford. This study works through the synthesis of tiopronin and the costs associated with the synthesis in our lab. The process includes the combination of 2-chloropropionic acid and thionyl chloride forming ⍺-chlorpromazine which is then involved in a coupling reaction with glycine and sodium carbonate to form ⍺-chloropropionylglycine. This product was then combined with sodium sulfide nonahydrate, sulfur, and sodium hydroxide to form tiopronin. Results and cost analysis will be described.