Synthesis of 2-aminothiazole Derivatives as Potential Treatments of Mycetoma
Session Number
Project ID: MEDH 09
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
19-4-2023 9:05 AM
End Date
19-4-2023 9:20 AM
Abstract
Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in limbs, causing deformity, physical disability, and in severe cases death. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. Although progress is being made by the countries of origin it is difficult to control the disease due to its prevalence in more rural localities as well as a lack of education regarding identification and treatment. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. To combat this disease, an open-source project has been created to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.
Synthesis of 2-aminothiazole Derivatives as Potential Treatments of Mycetoma
Fungal mycetoma is a neglected tropical disease that destroys skin, subcutaneous, and bone tissues in limbs, causing deformity, physical disability, and in severe cases death. The disease spreads after contamination of wounds, typically on the feet or legs of a patient. There are over 70 identified fungal species that can cause fungal mycetoma after infecting humans. Although progress is being made by the countries of origin it is difficult to control the disease due to its prevalence in more rural localities as well as a lack of education regarding identification and treatment. The disease is most prevalent in arid, tropical regions of Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, Thailand, and Yemen. Despite its effects, fungal mycetoma is still poorly understood and no treatments have been found for the disease. To combat this disease, an open-source project has been created to find drug lead compounds that impact the disease. In our research, we synthesized different 2-aminothiazole analogs that can be sent to our collaborators for further testing to determine their biological efficacy against fungal mycetoma.