Biocompatibility and Functional Impact of a Wireless Bladder Pressure System
Session Number
MEDH 20
Advisor(s)
Dr. Arun Sharma, Northwestern University, Feinberg School of Medicine
Discipline
Medical and Health Sciences
Start Date
17-4-2025 11:25 AM
End Date
17-4-2025 11:40 AM
Abstract
Bladder dysfunctions in pediatric patients, specifically those with spina bifida, often lead to neurogenic bladder, which necessitates continuous monitoring. Traditional diagnostic methods like urodynamic studies(UDS) are invasive and only provide intermittent data, which limits long-term management. This study evaluates a transient wireless strain system for continuous bladder pressure monitoring, aiming to reduce patient discomfort and improve clinical outcomes.
Using a rodent model, bladder functionality and inflammatory responses following device implantation were assessed. Results indicate minimal changes in bladder pressure, with stable bladder compliance and leak point pressure over time, demonstrating no significant disruption to bladder function. Histological analysis showed consistent muscle content and vascularization, with no signs of bladder atrophy. Trichrome staining confirmed preserved tissue integrity, while immunohistochemistry staining for macrophages(CD68) and neutrophils(MPO) revealed no significant inflammatory response, suggesting biocompatibility of the device.
These findings support the potential of the wireless strain system as a non-invasive alternative to traditional monitoring methods, offering real-time, continuous data without compromising bladder function. This technology could significantly enhance clinical care for pediatric patients with urological dysfunctions, reducing reliance on invasive procedures and improving long-term health outcomes.
Biocompatibility and Functional Impact of a Wireless Bladder Pressure System
Bladder dysfunctions in pediatric patients, specifically those with spina bifida, often lead to neurogenic bladder, which necessitates continuous monitoring. Traditional diagnostic methods like urodynamic studies(UDS) are invasive and only provide intermittent data, which limits long-term management. This study evaluates a transient wireless strain system for continuous bladder pressure monitoring, aiming to reduce patient discomfort and improve clinical outcomes.
Using a rodent model, bladder functionality and inflammatory responses following device implantation were assessed. Results indicate minimal changes in bladder pressure, with stable bladder compliance and leak point pressure over time, demonstrating no significant disruption to bladder function. Histological analysis showed consistent muscle content and vascularization, with no signs of bladder atrophy. Trichrome staining confirmed preserved tissue integrity, while immunohistochemistry staining for macrophages(CD68) and neutrophils(MPO) revealed no significant inflammatory response, suggesting biocompatibility of the device.
These findings support the potential of the wireless strain system as a non-invasive alternative to traditional monitoring methods, offering real-time, continuous data without compromising bladder function. This technology could significantly enhance clinical care for pediatric patients with urological dysfunctions, reducing reliance on invasive procedures and improving long-term health outcomes.