Todd B. Parrish, PhD; Northwestern University, Department of Radiology
Parkinson's disease (PD) is characterized by the degeneration of nigrostriatal dopaminergic neurons, resulting in dysfunctional cortico-striato-thalamiccortical loops. Parkinson's disease patients suffer from chronic movement disabilities as well as cognitive impairments and other nonmotor symptoms, which implies a systemwide effect on overall brain function. Because the disease currently has no cure, the discovery of a biomarker for specific PD symptoms is crucial for monitoring treatment potency. This study aimed to evaluate the validity of using functional connectivity between regions of the basal ganglia as a biomarker for specific symptoms of PD.
Modi, N., Yuan, L., & Parrish, T. B. (2015). Using resting-state functional connectivity of the basal ganglia as a biomarker for symptoms of Parkinson's disease [PowerPoint slides]. Retrieved from http://digitalcommons.imsa.edu/student_pr/14/