Todd B. Parrish, PhD; Northwestern University, Department of Radiology
Illinois Mathematics and Science Academy, IMSA, STEM, residential high school, gifted, student inquiry, student research, Parkinson's Disease, functional connectivity
Parkinson's disease (PD) is characterized by the degeneration of nigrostriatal dopaminergic neurons, resulting in dysfunctional cortico-striato-thalamiccortical loops. Parkinson's disease patients suffer from chronic movement disabilities as well as cognitive impairments and other nonmotor symptoms, which implies a systemwide effect on overall brain function. Because the disease currently has no cure, the discovery of a biomarker for specific PD symptoms is crucial for monitoring treatment potency. This study aimed to evaluate the validity of using functional connectivity between regions of the basal ganglia as a biomarker for specific symptoms of PD.
Modi, N., Yuan, L., & Parrish, T. B. (2015). Using resting-state functional connectivity of the basal ganglia as a biomarker for symptoms of Parkinson's disease [PowerPoint slides]. Retrieved from http://digitalcommons.imsa.edu/student_pr/14/