Kirsten Viola, Northwestern University
William Klein, Ph.D., Northwestern University
Aβ Oligomers (called AβOs) are small peptides that show early build-up in immunohistochemistry and immunochemistry studies, and appear before plaques in Alzheimer’s development. High levels of AβOs cause loss of memory performance and other pathological changes.Early presentation of AβOs makes them ideal for diagnostic targeting with AβO-specific antibodies Bound to magnetic nanostructures (MNSs) for MRI visibility. Further testing can determine effectiveness of future pharmaceuticals for AD therapy.
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Diagnostic AβO-targeted probes for Alzheimer’s Disease.
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