Dong-Hyun Kim, PhD; Northwestern University, Feinberg School of Medicine Department of Radiology
Kijung Kwak; Northwestern University, McCormick School of Engineering
Bo Yu, PhD, Department of Radiology Northwestern University, Feinberg School of Medicine
Due to the limitations or poor drug release kinetics and subsequent damage to adjacent normal digestive epithelial cells for drug eluting stents (DES), this project highlights the usage of gemcitabine-loaded mesoporous silica nanoparticles (gMSNP), which were coated onto a stent with biodegradable poly(lactic-coglycolic) acid (PLGA) polymer. The results showed improved drug release kinetics of the developed nanocomposite layers of the stent. Using our results, our DES will eventually reduce the rate of restenosis that can be induced by stents.
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Development of Double-Controlled Drug Eluting Stents with Nanotechnology.
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