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Document Type

Conference Paper/Presentation

Publication Date

10-2020

Advisor(s)

Dr. Jones Parker, PhD; Northwestern University, Feinberg School of Medicine

Abstract

Dopamine signaling is thought to alter the excitability of the striatum’s principal neurons (D1- and D2-SPNs). We used immunohistochemistry to quantify the expression of Fos, a marker of neural activity, in mice trained in a head-fixed, striatum-dependent fear conditioning task. We observed a relative increase in Fos-expressing D1- vs D2-SPNs, which may indicate how activity in these neurons facilitates motor learning. Our findings have implications for understanding disease processes that affect the dopamine system, such as Parkinson’s disease and schizophrenia.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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