Event Title

Leukocyte Telomere Length and Risk of Mortality: A Systematic Review

Session Number

C02

Advisor(s)

Brandon Pierce, University of Chicago

Location

A-115

Start Date

28-4-2016 12:45 PM

End Date

28-4-2016 1:10 PM

Disciplines

Biology

Abstract

The purpose of our investigation was to conduct a literature review of available studies that look at leukocyte telomere length and compare it to overall risk mortality. Leukocyte telomere length has been connected to aging and age related diseases. Our study compiled data from many studies to see if there were significant results to report. The different studies we chose were both proscriptive and retrospective that reported the relationship between leukocyte telomere length and overall mortality. The eight studies involved 90,612 individuals in which 13,892 individuals died. The pooled relative risks were adjusted to the shortest tertile and tested for heterogeneity. There was moderate heterogeneity between the studies. The pooled relative risk for all-cause mortality in individuals with the shortest third versus longest third of telomere length showed high association (RR=1.38). The studies exhibited low to moderate heterogeneity (I2=35.18%). Observational data showed that telomere length has an inverse relationship with mortality in about 90,612 individual. However, additional research is needed to get more absolute results.


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Apr 28th, 12:45 PM Apr 28th, 1:10 PM

Leukocyte Telomere Length and Risk of Mortality: A Systematic Review

A-115

The purpose of our investigation was to conduct a literature review of available studies that look at leukocyte telomere length and compare it to overall risk mortality. Leukocyte telomere length has been connected to aging and age related diseases. Our study compiled data from many studies to see if there were significant results to report. The different studies we chose were both proscriptive and retrospective that reported the relationship between leukocyte telomere length and overall mortality. The eight studies involved 90,612 individuals in which 13,892 individuals died. The pooled relative risks were adjusted to the shortest tertile and tested for heterogeneity. There was moderate heterogeneity between the studies. The pooled relative risk for all-cause mortality in individuals with the shortest third versus longest third of telomere length showed high association (RR=1.38). The studies exhibited low to moderate heterogeneity (I2=35.18%). Observational data showed that telomere length has an inverse relationship with mortality in about 90,612 individual. However, additional research is needed to get more absolute results.