Event Title

Principles and Mechanics of Nanomedicine in Aging

Advisor(s)

Dr. Dong-Hyun Kim; Northwestern University, Feinberg School of Medicine

Discipline

Medical and Health Sciences

Start Date

21-4-2021 9:10 AM

End Date

21-4-2021 9:25 AM

Abstract

Nanomedicine has been continuing to develop with many advances in the biomedical field. It aims to provide novel tools for diagnosis and treatments for patients with age-related diseases, such as cancer, atherosclerosis, insulin resistance, and various cardio-metabolic and neurodegenerative diseases. Despite recent advances, there is still a lack of effective treatments to prevent age-related diseases. Nanomedicine has the capability to target aging pathways. Studies have shown that the aging process is known to be associated with heightened oxidative stress and related systemic inflammation. In order to solve this problem, Northwestern University BIGMed Lab analyzed various nanodelivery systems and determined that metallic nanoparticles, mesoporous silica nanoparticles, and other multifunctional nanoparticles have the most ideal advantages in clinical applications that include simple synthesis, easy chemical modification, biocompatibility, and adjustable biophysical properties. The project considered the benefits and drawbacks of current cancer treatments that are in the field of nanomedicine. There is great potential for multifunctional nanocarriers in medical diagnostics, therapeutics, and molecular targeting that can efficiently deliver anti-aging biomolecules. The most successful nanodelivery systems must have optimal features for loading and releasing therapeutic agents with minimal side effects, and multifunctional nanocarriers are promising applications to combat pathological conditions associated with oxidative stress.

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Apr 21st, 9:10 AM Apr 21st, 9:25 AM

Principles and Mechanics of Nanomedicine in Aging

Nanomedicine has been continuing to develop with many advances in the biomedical field. It aims to provide novel tools for diagnosis and treatments for patients with age-related diseases, such as cancer, atherosclerosis, insulin resistance, and various cardio-metabolic and neurodegenerative diseases. Despite recent advances, there is still a lack of effective treatments to prevent age-related diseases. Nanomedicine has the capability to target aging pathways. Studies have shown that the aging process is known to be associated with heightened oxidative stress and related systemic inflammation. In order to solve this problem, Northwestern University BIGMed Lab analyzed various nanodelivery systems and determined that metallic nanoparticles, mesoporous silica nanoparticles, and other multifunctional nanoparticles have the most ideal advantages in clinical applications that include simple synthesis, easy chemical modification, biocompatibility, and adjustable biophysical properties. The project considered the benefits and drawbacks of current cancer treatments that are in the field of nanomedicine. There is great potential for multifunctional nanocarriers in medical diagnostics, therapeutics, and molecular targeting that can efficiently deliver anti-aging biomolecules. The most successful nanodelivery systems must have optimal features for loading and releasing therapeutic agents with minimal side effects, and multifunctional nanocarriers are promising applications to combat pathological conditions associated with oxidative stress.