Chemistry

Schedule

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2022
Wednesday, April 20th
8:50 AM

Isolation of Extracts of Ginger and their Antimicrobial properties

Jesse Park, Illinois Mathematics and Science Academy

8:50 AM - 9:05 AM

The intention of this project was to find potential antimicrobial properties within ginger. This was done by isolating gingerol, shogaol, and zingiberene. These compounds are the defining components of ginger. After extraction, each compound was individually tested for antimicrobial properties. The effectiveness of the compounds was observed.

Substituent Effects on Phenol

Elizabeth Alcala, Illinois Mathematics and Science Academy
Ramzi Daki '23, Illinois Mathematics and Science Academy

8:50 AM - 9:05 AM

This project focuses on how adding various substituents to the already existing phenolmolecule will influence its structure and stability. Phenol is an antiseptic often found in household cleaners and is also used in small amounts as an anesthetic. 11 non-metal substituents are added within the para location to see whether or not the said substituent will affect the molecule. Our ... Read More

Synthesis of Treatments for Mycetoma Disease

James Anterola, Illinois Mathematics and Science Academy
Jeff Duan, Illinois Mathematics and Science Academy
Renaldo Venegas, Illinois Mathematics and Science Academy

8:50 AM - 9:05 AM

Mycetoma is a commonly neglected tropical disease that leads to the development of tumors that may affect underlying bone (CDC, 2020). By carrying on from graduated students’ research from the previous year, we have analyzed a compound, Methyl Ether 6, that they have deemed as potentially fit for the treatment of the disease. Enforcing Lipinski’s rule of 5 in combination ... Read More

9:10 AM

Leishmaniasis: hit to lead synthesis of treatment

Jadesola Suleiman, Illinois Mathematics and Science Academy

9:10 AM - 9:25 AM

Leishmaniasis is a parasitic disease that is characterized by fevers, enlarged spleens, weight loss, and swollen glands. It primarily affects the tropical and subtropical regions of Earth, and is also classified as a neglected tropical disease. This study was done in collaboration with the Drugs for Neglected Diseases Initiative (DNDi) and the University of Otago. The goal of this project ... Read More

The Molecular Interaction Between c-KIT Receptor Protein (STI-571) and Threonine

Aubrey Hall, Illinois Mathematics and Science Academy
Michelle Sun, Illinois Mathematics and Science Academy

9:10 AM - 9:25 AM

STI-571’s role in the medical field is not as significant as other proteins, so we are interested in the logistics of its interaction with amino acids, such as Threonine. We applied the SPARTAN software to model the STI-571 molecule and Thr. We then made atomic substitutions, including changing a few Nitrogen atoms to Carbon atoms. Despite such changes, the distance ... Read More

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Feyikemi Ogunleye, Illinois Mathematics and Science Academy

9:10 AM - 9:25 AM

9:30 AM

Experimentation with Small Molecule Inhibitors

Gabriella Kanallakan, Illinois Mathematics and Science Academy

9:30 AM - 9:45 AM

In the field of drug discovery, the use of small molecule inhibitors have become a prevalent strategy when developing drugs. In the p53-MDM2 protein-protein interaction, many novel small molecule inhibitors in the past 10 years have entered clinical trials to inhibit this protein interaction. There are many different types of small molecule inhibitors for this inhibitor such as MDMX or ... Read More

Quantification of Polyreactive Antibodies in Cardiolipin Using Dinitrophenol

Keira Feliciano, Illinois Mathematics and Science Academy
Vanessa Rodriguez, Illinois Mathematics and Science Academy

9:30 AM - 9:45 AM

Antibodies play a critical role in the immune system to recognize and defend the body from antigens. While most antibodies bind to one unique antigen due to the affinity maturation process, some antibodies bind with low affinity to multiple unrelated antigens, which is termed polyreactivity. In serum, there are many different polyreactive antibodies, of which have different affinities. Thus, using ... Read More

Synthesis of Fenarimol Derivatives as Potential Treatments for Mycetoma

Ethan Brazelton, Illinois Mathematics and Science Academy
Avdhan Kandikattu '22, Illinois Mathematics and Science Academy

9:30 AM - 9:45 AM

Antifungal therapy against eumycetoma, the fungal form of the infectious disease known as Mycetoma, has shown to be less than 27% effective, leading to the need for amputations and frequent surgeries. To find methods to control the predominant causative agent, Madurella mycetomatis, the crowdsourced MycetOS project was created with the intention of taking advantage of online communication between researchers. In ... Read More

10:05 AM

Chimeric Dynorphin-Morphine and their Resulting Interactions with Kappa and Mu Opioid Receptors

Matthew Torres '22, Illinois Mathematics and Science Academy

10:05 AM - 10:20 AM

Opioids are a drug that is often used as an analgesic. They work by binding to receptors in the brain, creatively known as “opioid receptors.” There are three main opioid receptors: the kappa receptor, the mu receptor, and the delta receptor. The delta and mu receptors are responsible for euphoria, addiction, and the most dangerous aspects of overdose, as well ... Read More

Minimizing Harmful Emissions from Common Explosives

Anthony Kholoshenko, Illinois Mathematics and Science Academy

10:05 AM - 10:20 AM

The intention of this molecular modeling chemistry project was to minimize harmful emissions from the common explosives trinitrotoluene (TNT) and composition-4 (C4). The explosives were modeled in Spartan, a molecular modeling software that allows for a variety of molecular calculations. Exothermic activation energy calculations were completed to understand initial energies required in the explosions and visualize how those energies fluctuate ... Read More

10:25 AM

Design and Synthesis of Emtricitabine Analogs as Potential Treatments for HIV

Dean Oquendo, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

Emtricitabine is a drug used to treat Human Immunodeficiency Virus Infection by slowing the progression of the virus in the body. Previously, a compound with a better binding affinity that was designed using computer aided drug design was found. The goal of this study is to synthesize the compound in the lab and test the product produced. The chemical synthesis ... Read More

Methane Removal Using Zeolites: A Computational Analysis

Aditi Kumar, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

Global warming is a pressing problem in the world today and it is exacerbated by the release of greenhouse gases, such as methane, into the atmosphere. Zeolites are being examined as a potential solution to the methane problem because they have a unique structure that can trap molecules. In particular, zeolites containing transitional metals show promise in oxidization reactions. Methane ... Read More

10:45 AM

Designing Potential Inhibitors of SARS-CoV-2’s Main Protease from (2S)-N-(4-carbamoylphenyl)oxolane-2-carboxamide

Kelly Cruz, Illinois Mathematics and Science Academy
Kenith Taukolo, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

With the rise in cases of SARS-CoV-2, it is imperative to discover a drug—in this case, an oral drug—to combat the virus’s ability to swiftly replicate. Fragment-based drug discovery provides a useful starting point in regards to the design of inhibitors rather than utilizing larger molecules. Due to the small size of these fragments, they can bind themselves to the ... Read More

On the Favorability of the Initiation Reaction of Polymerization of Various Polymers

Will McClain '22, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Polymers such as polystyrene, polyvinyl chloride (PVC), and nylon are very useful materials; they’re used in everything from packaging to piping to other everyday plastics. Every polymer is made up of many, many monomers stitched together to make a new substance. Their syntheses are very elaborate processes and are made up of multiple steps. The step to focus on is ... Read More

Uncovering an Improved Version of Donepezil, an Alzheimer’s Treatment

Amrut Pennaka, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Alzheimer’s disease, a form of dementia that declines cognitive function, is one of the world’s most prevalent diseases, currently with no cure discovered. Many drug therapies for the treatment of Alzheimer’s are centered around the cholinergic hypothesis, which states that the decrease of acetylcholine (ACh), a crucial neurotransmitter, is the start of the development of Alzheimer’s. To counter this, most ... Read More