Event Title

Synthesis of Fenarimol Derivatives as Potential Treatments for Mycetoma

Session Number

Project ID: CHEM 11

Advisor(s)

Dr. John Thurmond, Illinois Mathematics and Science Academy

Discipline

Chemistry

Start Date

20-4-2022 9:30 AM

End Date

20-4-2022 9:45 AM

Abstract

Antifungal therapy against eumycetoma, the fungal form of the infectious disease known as Mycetoma, has shown to be less than 27% effective, leading to the need for amputations and frequent surgeries. To find methods to control the predominant causative agent, Madurella mycetomatis, the crowdsourced MycetOS project was created with the intention of taking advantage of online communication between researchers. In particular, a fenarimol analog was found to be one of the most potent compounds active in vitro. Our goal was to synthesize derivatives of this lead compound so that partnering researchers through MycetOS would be able to test their potential and effectiveness in treating Mycetoma. This project has successfully synthesized compounds to be tested for their usability.

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Apr 20th, 9:30 AM Apr 20th, 9:45 AM

Synthesis of Fenarimol Derivatives as Potential Treatments for Mycetoma

Antifungal therapy against eumycetoma, the fungal form of the infectious disease known as Mycetoma, has shown to be less than 27% effective, leading to the need for amputations and frequent surgeries. To find methods to control the predominant causative agent, Madurella mycetomatis, the crowdsourced MycetOS project was created with the intention of taking advantage of online communication between researchers. In particular, a fenarimol analog was found to be one of the most potent compounds active in vitro. Our goal was to synthesize derivatives of this lead compound so that partnering researchers through MycetOS would be able to test their potential and effectiveness in treating Mycetoma. This project has successfully synthesized compounds to be tested for their usability.