Synthesis of Fenarimol Derivatives as Potential Treatments for Mycetoma
Session Number
Project ID: CHEM 11
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
20-4-2022 9:30 AM
End Date
20-4-2022 9:45 AM
Abstract
Antifungal therapy against eumycetoma, the fungal form of the infectious disease known as Mycetoma, has shown to be less than 27% effective, leading to the need for amputations and frequent surgeries. To find methods to control the predominant causative agent, Madurella mycetomatis, the crowdsourced MycetOS project was created with the intention of taking advantage of online communication between researchers. In particular, a fenarimol analog was found to be one of the most potent compounds active in vitro. Our goal was to synthesize derivatives of this lead compound so that partnering researchers through MycetOS would be able to test their potential and effectiveness in treating Mycetoma. This project has successfully synthesized compounds to be tested for their usability.
Synthesis of Fenarimol Derivatives as Potential Treatments for Mycetoma
Antifungal therapy against eumycetoma, the fungal form of the infectious disease known as Mycetoma, has shown to be less than 27% effective, leading to the need for amputations and frequent surgeries. To find methods to control the predominant causative agent, Madurella mycetomatis, the crowdsourced MycetOS project was created with the intention of taking advantage of online communication between researchers. In particular, a fenarimol analog was found to be one of the most potent compounds active in vitro. Our goal was to synthesize derivatives of this lead compound so that partnering researchers through MycetOS would be able to test their potential and effectiveness in treating Mycetoma. This project has successfully synthesized compounds to be tested for their usability.