The Synthesis of Cycloserine and market price analysis
Session Number
Project ID: MEDH 06
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
19-4-2023 10:05 AM
End Date
19-4-2023 10:20 AM
Abstract
Tuberculosis, caused by Mycobacterium tuberculosis, a bacterial pathogen that attacks macrophages by puncturing the membrane resulting in cell apoptosis, has been known to be drug-resistant, leaving many patients at risk for a worsening condition. Cycloserine is a second-line treatment for Multi-drug resistant tuberculosis (MDR-TB) in which the cyclic analog to D-alanine targets alanine racemase and D-alanine ligase, blocking the formation of the bacterial cell wall. After an excessive price hike in 2015, initially a 2100% increase and currently a 110% increase, many could not afford treatment. This study drives to synthesize cycloserine for less than the listed price sold. This process is completed by multistep synthesis of cycloserine and then cost analysis. Described in the study are the results and cost analysis.
The Synthesis of Cycloserine and market price analysis
Tuberculosis, caused by Mycobacterium tuberculosis, a bacterial pathogen that attacks macrophages by puncturing the membrane resulting in cell apoptosis, has been known to be drug-resistant, leaving many patients at risk for a worsening condition. Cycloserine is a second-line treatment for Multi-drug resistant tuberculosis (MDR-TB) in which the cyclic analog to D-alanine targets alanine racemase and D-alanine ligase, blocking the formation of the bacterial cell wall. After an excessive price hike in 2015, initially a 2100% increase and currently a 110% increase, many could not afford treatment. This study drives to synthesize cycloserine for less than the listed price sold. This process is completed by multistep synthesis of cycloserine and then cost analysis. Described in the study are the results and cost analysis.