Session III Project Presentations (20 min. + 5 min. Q & A)

11:25 am - 11:50 am
11:55 am - 12:20 pm


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Wednesday, April 19th
11:25 AM

Knocking Out the β-catenin from Induced Astrocytes using CRISPR/Cas9 Lentiviral Approach

Amogh Shetty '23, Illinois Mathematics and Science Academy

11:25 AM - 11:50 AM

Astrocytes are one of the most abundant cell types in the central nervous system (CNS), playing an important role in regulating glutamate uptake, neuroinflammatory response, blood brain barrier permeability, and neuronal health. In the past decade, hiPSCs (human induced pluripotent stem cells) were successfully demonstrated to differentiate into induced astrocytes (iAs), and recently have been shown to robustly express the ... Read More

The Effect of Cutaneous Electrical Stimulation on Hypertonia in Chronic Hemiparetic Stroke

Shreya Chakraborty '23, Illinois Mathematics and Science Academy
Yina Wang '23, Illinois Mathematics and Science Academy

11:25 AM - 11:50 AM

Cumulating evidence suggests that upregulation of corticoreticulospinal pathways following a stroke-induced loss of corticobulbar projections drives spinal motoneuro hyper-excitability. In turn, individuals with stroke experience increased muscl tone (i.e., hypertonia) and associated hyperactive stretch reflexes (i.e., spasticity). It has been shown that applying low-intensity (sub-motor-threshold) electrical stimulation to the skin reduces spasticity in individuals with hemiparetic stroke, as quantified by ... Read More

The Isomorphy Classes of the Special Orthogonal Group of Low Dimension in Characteristic 2

Shiqi Cheng '23, Illinois Mathematics and Science Academy

11:25 AM - 11:50 AM

In 1926, Cartan introduced the concept of real symmetric spaces as a class of homogeneous Riemannian manifolds, where a symmetric space is defined as the homogeneous space $G/H$ with $G$ a reductive group and $H=G^{\theta}=\{g\in G|\theta(g)=g\}$, the fixed-point group of an $n$-automorphism. Of special interest are automorphism of order 2, also called involutions. In this project we focused on classifying ... Read More

11:55 AM

A local ancestry-based assessment of common variants to finetune risk profiles of Parkinson’s disease (PD)

Dhruv Patel '23, Illinois Mathematics and Science Academy

11:55 AM - 12:20 PM

Parkinson’s disease (PD) is a severe neurodegenerative disease resulting from complex interactions between genetic and environmental factors. Past studies have estimated the genetic heritability of PD at around 24-60%, but they have examined samples of European ancestry as genetically homogenous.

Historical trends, however, find that Northern and Southern European tribes interbred between 440 and 1,080 CE, leading to 2-100 different ... Read More

Automatic Datacard Generation and Significance Estimation with Punzi Criterion for Higgs Analyses

Gautham Anne '23, Illinois Mathematics and Science Academy

11:55 AM - 12:20 PM

In order to perform a statistical analysis of Higgs searches, datacards are used to encode the observed and expected events after event selection to discriminate between signal and background. We developed a framework to incorporate into our analysis group’s framework to automatically generate datacards. In addition, we utilized the Higgs Combine Tool to test combining multiple generated datacards. In the ... Read More

Space-Time Conflict Spheres for Constrained Multi-Agent Motion Planning

Anirudh Chari '24, Illinois Mathematics and Science Academy

11:55 AM - 12:20 PM

1.3 million people are killed in road accidents each year, and 94% of these accidents are caused by human error. This has motivated advancements in autonomous vehicle technology, and more recently, connected autonomous vehicles (CAVs). CAVs communicate location and intention information with each other over the air, and the prospect of cooperative planning within a system of CAVs promises greater ... Read More