Meta Analysis of multifactorial Etiology, Epidemiology, and Implications of Orofacial Clefts
Abstract
Orofacial clefts (OFCs), including cleft lip (CL) and palate (CP), are common birth defects with significant impacts on speech, nutrition, and psychosocial development. This review discusses the diverse manifestation and classification of OFCs, the latest genetic findings, and advancements in management. Genetic factors, particularly those associated with syndromic and nonsyndromic OFCs, are explored, alongside environmental contributors such as smoking, alcohol, and nutrition. Various classification systems and diagnostic modalities are examined, emphasizing the importance of early detection and interdisciplinary care. Surgical interventions, including cleft lip and palate repairs, are discussed, highlighting the need for tailored approaches and ongoing dental and orthodontic care. Overall, successful management of OFCs requires a comprehensive, multidisciplinary approach to optimize both function and aesthetics, ultimately improving the quality of life for affected individuals.
Meta Analysis of multifactorial Etiology, Epidemiology, and Implications of Orofacial Clefts
Orofacial clefts (OFCs), including cleft lip (CL) and palate (CP), are common birth defects with significant impacts on speech, nutrition, and psychosocial development. This review discusses the diverse manifestation and classification of OFCs, the latest genetic findings, and advancements in management. Genetic factors, particularly those associated with syndromic and nonsyndromic OFCs, are explored, alongside environmental contributors such as smoking, alcohol, and nutrition. Various classification systems and diagnostic modalities are examined, emphasizing the importance of early detection and interdisciplinary care. Surgical interventions, including cleft lip and palate repairs, are discussed, highlighting the need for tailored approaches and ongoing dental and orthodontic care. Overall, successful management of OFCs requires a comprehensive, multidisciplinary approach to optimize both function and aesthetics, ultimately improving the quality of life for affected individuals.