Biology

Breast cancer is one of the most rampant malignancies in women around the world. The treatment for breast cancer consists of, but is not limited to, surgery, chemotherapy, endocrine therapy, and radiotherapy. Tamoxifen and Paclitaxel are the cornerstones of endocrine therapy drugs and chemotherapy drugs, respectively. Drug resistance, which includes primary resistance and consecutive resistance, is the biggest reason for ... Read More

Taste sensation is used to detect nutritious foods and avoid potentially toxic ones. Different animals have evolved varying tongue morphologies to match their ecological niche. For example, ferrets have evolved to have papillae and taste buds to best suit their diet consisting of small mammals like rabbits, rodents, and eggs often found in wooded areas and marshes where ferrets reside. ... Read More

This paper aims to examine the complex interplay of bone morphogenetic protein 9 (BMP-9) with osteogenesis, osteosarcoma, and its many other functions in the arena of research and translation into clinical therapeutics. Six recombinant adenovirus lines containing different heparin-binding (HB) domains that can increase the osteogenic activity of BMP-9 were constructed and then separated into two groups. One group of ... Read More

Intramembranous bone regeneration is an essential process for skeletal repair involving the direct differentiation of mesenchymal cells into osteoblasts. This study examines the formation of osteoblasts after marrow ablation surgery, a controlled injury model, to build understanding of intramembranous bone regeneration in haplotype mice, and how genetic variation may influence regenerative capabilities. Following surgery, femur samples were collected, frozen in ... Read More

The study investigates how localized geometric constraints affect the conformations adopted by the amino acid side-chain dihedral angles in proteins. Without knowledge of the fundamental principles upon which protein structure rests, no protein can be designed, nor mutations in natural proteins analyzed. The specific aim is to establish the importance of geometry and physicochemical properties toward dihedral angle combinations by ... Read More

The efficacy of chemotherapeutic drug regimens has been a longstanding concern for cancer treatments, highlighting the need for research on how they could become more effective. A possible answer could lie in the field of epitranscriptomics, in which chemical modifications are made to RNA to affect gene expression. In this study, we aimed to find the effects of drug treatment ... Read More

The nucleolus is a membraneless subnuclear structure involved in ribosome biogenesis and cell regulation. This study aimed to determine whether nucleolar conditions reflect viral stresses in other parts of the cell. Human cells were infected with the H1N1 virus, and ARTR-seq was used to enrich nucleolar RNA for sequencing. Sequenced transcripts were mapped to the human genome, followed by differential ... Read More

Endocrine therapy, the standard treatment for estrogen receptor-positive breast cancer, often fails due to drug resistance. It has been shown that this resistant phenotype is linked to lower ceramide levels and increased sensitivity to ceramide-induced cell death in the ER+ cell lines and that the protein TRAM-1 may play a crucial role in the formation of ET-resistant cells. Our research ... Read More

Most of the human population has had a peanut before. This staple of worldwide cuisine has been proven to have cardiovascular, digestive, and nutritional benefits. In this systematic review, we aimed to assess the effects of peanuts on cognition. We measured cognition under three domains: Memory, Reaction Time & Processing Speed, and Global Cognitive Function. Five studies met our inclusion ... Read More

Wastewater-based epidemiology (WBE) is a technique used to assess the health of a population by analyzing the relative concentrations of certain substances within wastewater. The COVID-19 pandemic heightened interest in WBE as a cost-effective, anonymous, and accessible tool for tracking community-wide trends of respiratory viruses such as Influenza A & B and RSV. However, questions remain about its applicability to ... Read More

Triple-Negative Breast Cancer (TNBC) is an aggressive subtype characterized by high metastatic potential and limited treatment options. Previous research done in the Minshall Lab suggests that the Kv11.1 K⁺ channel activator NS1643 reduces TNBC metastasis in part by enhancing β-catenin interaction with desmosomal proteins, thereby strengthening cell-cell and cell-matrix adhesion. Building on these findings, we investigated the impact of NS1643 ... Read More

The human lung contains two major types of basal cells: large airway basal cells (LABCs) and distal airway basal cells (DABCs). LABS are found in proximal airways of the lung, such as the trachea or large bronchi, while DABCs are found in the periphery, alveolar regions of the lung. Using known single cell data, the TP63 transcription factor is expressed ... Read More