| 2026 | ||
| Wednesday, April 15th | ||
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| 10:15 AM |
Reduced Atrial Prolactin (PRL) Expression as a Potential Biomarker for Atrial Fibrillation Aarnav Jain, Illinois Math and Science Academy A149 10:15 AM - 11:00 AM Prolactin (PRL) is a multifunctional hormone primarily known for its roles in lactation and 66 reproduction, but it is also expressed in many non-reproductive tissues. In the present study, PRL expression in cardiac tissue was investigated and its potential as a biomarker for atrial fibrillation (AF) was evaluated. Large-scale tissue-specific expression data from the GTEx database were analyzed using BioJupies. ... Read More |
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| 10:15 AM |
The Role of SPTSSB in the Synthesis of Long Chain Ceramides and Its Effect on Skin Barrier Lisa Choi, Illinois Math and Science Academy B115 10:15 AM - 11:00 AM Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with impaired barrier function and altered ceramide composition in the stratum corneum. Disruption of long-chain ceramide synthesis contributes to defective lipid organization and abnormal keratinocyte differentiation. We investigated the role of serine palmitoyltransferase small subunit B 51 (SPTSSB), a regulatory component of the rate-limiting enzyme complex in de novo ceramide ... Read More |
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| 11:10 AM |
Inducible Knockdown of t6A Pathway Genes in PEO1 and PEO4 Ovarian Cancer Cells Hayeon (Lily) Kwak, Illinois Math and Science Academy A151 11:10 AM - 11:55 AM Ovarian cancer is often classified as a cold tumor due to its low tumor mutation burden (TMB) and limited neoantigen expression, which results in poor responses to immune checkpoint inhibitor therapy. One possible strategy to increase neoantigen production is to disrupt the fidelity of protein translation. The tRNA modification N6-threonylcarbamoyladenosine (t6A) plays an essential role in maintaining translation accuracy by ... Read More |
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| 11:10 AM |
Novel nNOS Inhibitors Targets Aβ Oligomer-Driven pathology in Alzheimer’s Disease Grace Rhee, Illinois Math and Science Academy A123 11:10 AM - 11:55 AM Alzheimer’s Disease (AD) is a neurodegenerative disorder that affects nearly 57 million individuals worldwide. An effect of the disease is characterized by a disruption in the signal from the production of Nitric Oxide (NO), which highly contributes to negative symptoms that AD patients experience. In neurons, nitric oxide is mainly produced by a compound called neuronal nitric oxide synthase (nNOS). ... Read More |
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| 11:10 AM |
Amelia Szeto, Illinois Math and Science Academy A119 11:10 AM - 11:55 AM This study builds on prior work optimizing Fiji (ImageJ), a widely used image-processing tool in cell and molecular biology, and develops a standard protocol to identify and quantify cardiomyocyte subtypes. The primary objective is to analyze different microscopy images of differentiating iPSC cultures using Fiji. This study will address the current challenges of accurately measuring cardiomyocyte differentiation efficiency, manual cell ... Read More |
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| 2:15 PM |
Amit Prakash, Illinois Math and Science Academy A117 2:15 PM - 3:00 PM Triple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy through subclonal evolution, but most existing computational oncology methods do not fully account for this. They reconstruct clonal structure or identify resistance-associated features after treatment rather than forecast resistance accumulation on evolving tumor lineages. This project develops a Bayesian deep phylogenetic pipeline that combines phyddle-based inference of tumor topology and lineage-specific ... Read More |
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| 2:15 PM |
Neil Sitapara, Illinois Math and Science Academy A149 2:15 PM - 3:00 PM Stroke, which impacts millions of people worldwide, can cause long-lasting motor impairments which impact their daily life. Hypertonia, one of these debilitating symptoms, is the increase in muscle tone due to upper motor neuron lesions. It is caused by damage to the central nervous system, specifically the brain or spinal cord, which disrupts signals controlling muscle contraction. Living with hypertonia ... Read More |
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