Document Type

Conference Paper/Presentation


International Student Science Fair (ISSF) 2019 - March 18-22, 2019

Publication Date



Ryan Ross, Ph.D.; Rush University


Alzheimer's Disease, Osteoporosis, Rush University, 5xFAD mouse model, bone density, trabecular bone, cortical bone


  • Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. Previous research has found that AD and osteoporosis may overlap [4].
  • Observational studies demonstrate a correlation between the osteoporosis and AD that suggest, rather than one condition causing the other, both conditions are related by a common underlying mechanism [4].
  • Previous studies have investigated bone mass in mouse models that recapitulate the pathology of AD [4].
  • This study focuses on the 5xFAD mouse model, another AD mouse model that exhibits a more aggressive form of AD. Thus, the 5xFAD mouse model rapidly recapitulates major features of AD amyloid pathway: rapidly accumulating Aβ42 in the brain, early amyloid deposition and gliosis, robust intraneuronal Aβ labeling, neurodegeneration and neuron loss.
  • The goal of this study was to investigate the skeleton of the 5xFAD mice and compare its bone density to age-matched healthy control mice.



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