Ryan Ross, PhD; Rush University
Alzheimer's Disease, Osteoporosis, Rush University, 5xFAD mouse model, bone density, trabecular bone, cortical bone
- Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. Previous research has found that AD and osteoporosis may overlap .
- Observational studies demonstrate a correlation between the osteoporosis and AD that suggest, rather than one condition causing the other, both conditions are related by a common underlying mechanism .
- Previous studies have investigated bone mass in mouse models that recapitulate the pathology of AD .
- This study focuses on the 5xFAD mouse model, another AD mouse model that exhibits a more aggressive form of AD. Thus, the 5xFAD mouse model rapidly recapitulates major features of AD amyloid pathway: rapidly accumulating Aβ42 in the brain, early amyloid deposition and gliosis, robust intraneuronal Aβ labeling, neurodegeneration and neuron loss.
- The goal of this study was to investigate the skeleton of the 5xFAD mice and compare its bone density to age-matched healthy control mice.
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The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Mouse Model.
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