Poster or Presentation Title
Glucosamine from Hydrolysis of 3D Printing Chitosan for Osteoarthritis Treatment
Advisor(s)
Panuphong Pootawang
Sarun Nounjeen
Subjects
Chemistry
Abstract
This project aims to introduce a new way for osteoarthritis treatment which is expected to increase in the future. Glucosamine is the main subject for a treatment, which can be derived by hydrolyzing chitosan. This project also includes extraction of chitosan from shrimp waste to make a worthy use of food waste from industry. In this project, 3D printer is applied to print chitosan gel since 3D printing is adjustable to form various shapes of the gel.
The research process begins with the extraction of chitosan from shrimp shells. For the next step, the percent of deacetylation of chitosan was determined by titration technique and determined characteristics by FTIR and XRD analysis. Chitosan gel was prepared by dissolving chitosan with the mixed acetic acid, lactic acid, and citric acid. Finally, the 3D-printer for using in the gel printing was designed by the modification of the nozzle to match and fit for fabrication of chitosan gel. From the experiment, it indicates that chitosan gel formation could be readily prepared. The deacetylation percentage and FTIR analysis indicate that the synthesized chitosan is comparable to commercial chitosan. However, due to high crystallity of the chitosan, from XRD analysis, it made chitosan could not be efficiently dissolved into gel. Therefore, an adaptation of chitosan extraction was done. It was to heat in every steps of extraction. It resulted in better dissolving ability and gel formation and was printable by the modified 3D-printer.
Included in
Biochemistry Commons, Body Regions Commons, Medicinal-Pharmaceutical Chemistry Commons, Musculoskeletal System Commons, Polymer and Organic Materials Commons, Polymer Chemistry Commons
Glucosamine from Hydrolysis of 3D Printing Chitosan for Osteoarthritis Treatment
This project aims to introduce a new way for osteoarthritis treatment which is expected to increase in the future. Glucosamine is the main subject for a treatment, which can be derived by hydrolyzing chitosan. This project also includes extraction of chitosan from shrimp waste to make a worthy use of food waste from industry. In this project, 3D printer is applied to print chitosan gel since 3D printing is adjustable to form various shapes of the gel.
The research process begins with the extraction of chitosan from shrimp shells. For the next step, the percent of deacetylation of chitosan was determined by titration technique and determined characteristics by FTIR and XRD analysis. Chitosan gel was prepared by dissolving chitosan with the mixed acetic acid, lactic acid, and citric acid. Finally, the 3D-printer for using in the gel printing was designed by the modification of the nozzle to match and fit for fabrication of chitosan gel. From the experiment, it indicates that chitosan gel formation could be readily prepared. The deacetylation percentage and FTIR analysis indicate that the synthesized chitosan is comparable to commercial chitosan. However, due to high crystallity of the chitosan, from XRD analysis, it made chitosan could not be efficiently dissolved into gel. Therefore, an adaptation of chitosan extraction was done. It was to heat in every steps of extraction. It resulted in better dissolving ability and gel formation and was printable by the modified 3D-printer.
Comments
Recipient of the Most Ambitious Research Award