Session 1G: PI5P: Preparation of a PMB Inositol Ring
Session Number
Session 1G :2nd Presentation
Advisor(s)
Brent Chandler, Illinois College
Location
Room A117
Start Date
28-4-2017 8:30 AM
End Date
28-4-2017 9:45 AM
Abstract
The scarce naturally occurring phosphatidylinositol phosphate (PIP) Phosphatidylinositol-5-phosphate (PI5P) has been found in abnormally high concentrations in lung cancer cells. Due to its instability, PI5P is the only species of PIPs not to have been synthesized before. This research is aimed at synthesizing PI5P in sufficient quantities to facilitate studies on the role of PI5P in the rate of transcription in lung cancer cells. Synthesizing PI5P involves a multi-step process beginning with myo-inositol leading to the production of PI5P and its enantiomer. To date, four of these steps have been successfully completed. In the next phase of the project, six proposed approaches will be evaluated to cleave the acetal group on the compound produced thus far (Compound 9), and then the resulting compound will be attached to diacylglycerol side-chains to synthesize PI5P and its enantiomer.
Session 1G: PI5P: Preparation of a PMB Inositol Ring
Room A117
The scarce naturally occurring phosphatidylinositol phosphate (PIP) Phosphatidylinositol-5-phosphate (PI5P) has been found in abnormally high concentrations in lung cancer cells. Due to its instability, PI5P is the only species of PIPs not to have been synthesized before. This research is aimed at synthesizing PI5P in sufficient quantities to facilitate studies on the role of PI5P in the rate of transcription in lung cancer cells. Synthesizing PI5P involves a multi-step process beginning with myo-inositol leading to the production of PI5P and its enantiomer. To date, four of these steps have been successfully completed. In the next phase of the project, six proposed approaches will be evaluated to cleave the acetal group on the compound produced thus far (Compound 9), and then the resulting compound will be attached to diacylglycerol side-chains to synthesize PI5P and its enantiomer.