Session 2E: Identifying Aβ Oligomers Species (AßOs) and pTau in Transgenic mice with Alzheimer’s
Session Number
Session 2E: 4th Presentation
Advisor(s)
Erika Cline, Northwestern University
Location
Room A113
Start Date
28-4-2017 10:00 AM
End Date
28-4-2017 11:15 AM
Abstract
In the field of Alzheimer's Disease (AD), there is great debate about the role of Aβ Oligomers Species (AßOs) and pTau in the pathogenesis of AD, a progressive neurodegenerative disease. Since there is still ambiguity about the pattern of AßO buildup in correlation with other pathological events associated with AD, it is important to study the formation and onset of AD in mice. This study analyzed the brain tissue of transgenic mice (FAD5x, wide type) with respect to age (3, 6, and 9 months) and gender (male and female) to measure AßO levels in the progression of AD. With the use of biochemical methods such as dot blots, brain tissues were studied to determine and quantify the presence of AßOs to correlate with pTau buildup and neuron dysfunction. The results will be presented at IMSAloquium and the role and quantification of AßOs and pTau in mice brains will be discussed.
Session 2E: Identifying Aβ Oligomers Species (AßOs) and pTau in Transgenic mice with Alzheimer’s
Room A113
In the field of Alzheimer's Disease (AD), there is great debate about the role of Aβ Oligomers Species (AßOs) and pTau in the pathogenesis of AD, a progressive neurodegenerative disease. Since there is still ambiguity about the pattern of AßO buildup in correlation with other pathological events associated with AD, it is important to study the formation and onset of AD in mice. This study analyzed the brain tissue of transgenic mice (FAD5x, wide type) with respect to age (3, 6, and 9 months) and gender (male and female) to measure AßO levels in the progression of AD. With the use of biochemical methods such as dot blots, brain tissues were studied to determine and quantify the presence of AßOs to correlate with pTau buildup and neuron dysfunction. The results will be presented at IMSAloquium and the role and quantification of AßOs and pTau in mice brains will be discussed.
Comments
Additional team members: Dr. William Klein, Kirsten Viola, Anthea Weng, and Adrian Bebenek