Exploring the Potential of Cucurbiturils as Host Compounds in Host-Guest Complexes
Advisor(s)
Dr. Laura Kopff, Illinois Mathematics and Science Academy
Location
Room A119
Start Date
26-4-2019 9:45 AM
End Date
26-4-2019 10:00 AM
Abstract
Cucurbiturils (CB[n]) are macrocyclic compounds made from glycoluril monomers. They have the potential to act as host molecules in the formation of host-guest complexes with an array of substrates, including amino acids, hydrocarbons, and halogenated aromatic compounds. Cucurbit[6]uril (CB[6]) and Cucurbit[7]uril (CB[7]) were synthesized and characterized. Their ability to act as host complexes with both coumarin-1 dye and biphenyl was explored using UV-vis spectroscopy.
We synthesized CB[6] and CB[7] compounds and made nine solutions to figure out when combined how the absorbance peaks might change. Three solutions made of Coumarin 1 dye and HCl, another three solutions were made of Cyclodextrin and HCl, and the final three solutions were made from Biphenyl and methanol. We combined Biphenyl solutions and Cyclodextrin solutions and the Coumarin 1 dye solutions with Cyclodextrin solutions, and ran absorbance tests. For the Biphenyl there were consistent peaks at 204, 244, 252, 291, and 346 nm. Coumarin 1 dye showed peak patterns corresponding to each molarity. The 20 uM solution had peaks at 244, 291, 327 nm; in the 10 and 5 uM solution there was a peak at 260 nm.
Exploring the Potential of Cucurbiturils as Host Compounds in Host-Guest Complexes
Room A119
Cucurbiturils (CB[n]) are macrocyclic compounds made from glycoluril monomers. They have the potential to act as host molecules in the formation of host-guest complexes with an array of substrates, including amino acids, hydrocarbons, and halogenated aromatic compounds. Cucurbit[6]uril (CB[6]) and Cucurbit[7]uril (CB[7]) were synthesized and characterized. Their ability to act as host complexes with both coumarin-1 dye and biphenyl was explored using UV-vis spectroscopy.
We synthesized CB[6] and CB[7] compounds and made nine solutions to figure out when combined how the absorbance peaks might change. Three solutions made of Coumarin 1 dye and HCl, another three solutions were made of Cyclodextrin and HCl, and the final three solutions were made from Biphenyl and methanol. We combined Biphenyl solutions and Cyclodextrin solutions and the Coumarin 1 dye solutions with Cyclodextrin solutions, and ran absorbance tests. For the Biphenyl there were consistent peaks at 204, 244, 252, 291, and 346 nm. Coumarin 1 dye showed peak patterns corresponding to each molarity. The 20 uM solution had peaks at 244, 291, 327 nm; in the 10 and 5 uM solution there was a peak at 260 nm.