The Effects of Pepstatin A on Cathepsin D using GBM Cell Lines

Session Number

Project ID: BIO 23

Advisor(s)

Dr. Sowmya Anjur; Illinois Mathematics and Science Academy

Discipline

Biology

Start Date

22-4-2020 8:30 AM

End Date

22-4-2020 8:45 AM

Abstract

Glioblastoma multiforme (GBM) is a rapidly progressing brain cancer found to overexpress the biological marker Cathepsin D. Pepstatin A has been identified as a potential inhibitor of Cathepsin D in breast cancers. This study sought to verify the viability of Pepstatin A as a potential inhibitor of Cathepsin D in GBM cells lines by adding a solution of DMSO and Pepstatin A to GBM cells. A control was maintained for the comparison of cells treated with Pepstatin A and cells not treated. Exposing GBM to Pepstatin A should theoretically inhibit the progression of GBM. Future experimentation is planned to study the effects of Pepstatin D.

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Apr 22nd, 8:30 AM Apr 22nd, 8:45 AM

The Effects of Pepstatin A on Cathepsin D using GBM Cell Lines

Glioblastoma multiforme (GBM) is a rapidly progressing brain cancer found to overexpress the biological marker Cathepsin D. Pepstatin A has been identified as a potential inhibitor of Cathepsin D in breast cancers. This study sought to verify the viability of Pepstatin A as a potential inhibitor of Cathepsin D in GBM cells lines by adding a solution of DMSO and Pepstatin A to GBM cells. A control was maintained for the comparison of cells treated with Pepstatin A and cells not treated. Exposing GBM to Pepstatin A should theoretically inhibit the progression of GBM. Future experimentation is planned to study the effects of Pepstatin D.