Investigating Sex-Specific Effects of Gut Microbiome Perturbations on Alzheimer’s Pathology
Session Number
Project ID: MEDH 33
Advisor(s)
Dr. Sangram Sisodia; University of Chicago, Pritzker School of Medicine
Discipline
Medical and Health Sciences
Start Date
22-4-2020 9:45 AM
End Date
22-4-2020 10:00 AM
Abstract
Current evidence of the microbiome-gut-brain axis suggests that gut microbiome plays a key role in regulating microglial maturation and function. An altered microbiome in the gut has been characterized in Alzheimer’s disease (AD). In prior studies, the Sisodia lab has shown that antibiotic cocktail (ABX)-perturbed altered gut microbiome in APPPS1-21 male mice showed reduced brain amyloidosis which were restored after fecal microbiota transplantation (FMT) of age-matched APPPS1-21 mice. This demonstrates a causal relationship between AB plaque deposits and the gut microbiome in AD mouse models. However, the microbiome differences in APPPS1-21 transgenic (Tg) and Wild-Type (Wt) mice and their effects on AB pathology remains unknown. Here I propose FMT transplants of gut microbiome from Tg male mice and Wt male mice into ABX-treated APPS1-21 male mice to investigate any differences in their gut microbiome and the cause of AB pathology.
Investigating Sex-Specific Effects of Gut Microbiome Perturbations on Alzheimer’s Pathology
Current evidence of the microbiome-gut-brain axis suggests that gut microbiome plays a key role in regulating microglial maturation and function. An altered microbiome in the gut has been characterized in Alzheimer’s disease (AD). In prior studies, the Sisodia lab has shown that antibiotic cocktail (ABX)-perturbed altered gut microbiome in APPPS1-21 male mice showed reduced brain amyloidosis which were restored after fecal microbiota transplantation (FMT) of age-matched APPPS1-21 mice. This demonstrates a causal relationship between AB plaque deposits and the gut microbiome in AD mouse models. However, the microbiome differences in APPPS1-21 transgenic (Tg) and Wild-Type (Wt) mice and their effects on AB pathology remains unknown. Here I propose FMT transplants of gut microbiome from Tg male mice and Wt male mice into ABX-treated APPS1-21 male mice to investigate any differences in their gut microbiome and the cause of AB pathology.