Role of Estrogen Receptor in Breast Cancer Stem Cells
Advisor(s)
Dr. Jonna Frasor; University of Illinois at Chicago
Discipline
Medical and Health Sciences
Start Date
21-4-2021 10:05 AM
End Date
21-4-2021 10:20 AM
Abstract
In general, estrogen receptor positive breast cancers (ER+ BC) have a high treatability. However, these tumors often recur following endocrine therapy due to breast cancer stem cell (BCSC) activity. BCSC are a group of cells that possess numerous properties, such as self-renewal and the ability to survive independently in the circulation and contribute to breast cancer relapse. Many studies have attempted to understand the activity of BCSC in ER+ BC. However, the role that the active ER plays in regulating BCSC activity is not well established. Studies have arrived at different conclusions on the impact that ER has on BCSC. This review will discuss the different findings of studies that describe the different roles that the ER plays in breast cancer stem cell activity.
Role of Estrogen Receptor in Breast Cancer Stem Cells
In general, estrogen receptor positive breast cancers (ER+ BC) have a high treatability. However, these tumors often recur following endocrine therapy due to breast cancer stem cell (BCSC) activity. BCSC are a group of cells that possess numerous properties, such as self-renewal and the ability to survive independently in the circulation and contribute to breast cancer relapse. Many studies have attempted to understand the activity of BCSC in ER+ BC. However, the role that the active ER plays in regulating BCSC activity is not well established. Studies have arrived at different conclusions on the impact that ER has on BCSC. This review will discuss the different findings of studies that describe the different roles that the ER plays in breast cancer stem cell activity.