Event Title

Synthesizing and Cost Evaluating Tiopronin

Session Number

Project ID: MEDH 35

Advisor(s)

Dr. John Thurmond, Illinois Mathematics and Science Academy

Discipline

Medical and Health Sciences

Start Date

20-4-2022 9:10 AM

End Date

20-4-2022 9:25 AM

Abstract

Tiopronin is a prescription thiol drug used as medication to treat severe homozygous cystinuria. Although not an immediate threat it contains the risk of the formation of kidney stones. Tiopronin is used as a second-line therapy to control the rate of cysteine precipitation and excretion. The price of tiopronin has recently exploded from $1.50 to $30 per pill, a 1,900% increase in cost. The intent of our project is to make this drug for ourselves, and cost evaluate it to see if the price charged by pharmaceutical companies is fair. By following the instructions of a pre-existing patent, we conducted various steps to synthesize this drug. After distilling the solution, combining it with other chemical compounds, the 2- chloropropionic acid ended as an organic material. The NMR shows similarities between tiopronin and the organic material we made. Our findings indicate that tiopronin cost $2.38 to make 100 mg, a substantial decrease from the $30 per 100mg.

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Apr 20th, 9:10 AM Apr 20th, 9:25 AM

Synthesizing and Cost Evaluating Tiopronin

Tiopronin is a prescription thiol drug used as medication to treat severe homozygous cystinuria. Although not an immediate threat it contains the risk of the formation of kidney stones. Tiopronin is used as a second-line therapy to control the rate of cysteine precipitation and excretion. The price of tiopronin has recently exploded from $1.50 to $30 per pill, a 1,900% increase in cost. The intent of our project is to make this drug for ourselves, and cost evaluate it to see if the price charged by pharmaceutical companies is fair. By following the instructions of a pre-existing patent, we conducted various steps to synthesize this drug. After distilling the solution, combining it with other chemical compounds, the 2- chloropropionic acid ended as an organic material. The NMR shows similarities between tiopronin and the organic material we made. Our findings indicate that tiopronin cost $2.38 to make 100 mg, a substantial decrease from the $30 per 100mg.