Design and Synthesis of Analogs of Dasatinib as Potential Treatments for Chronic Myeloid Leukemia and Acute Lymphatic Leukemia
Session Number
Project ID: MEDH 07
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
19-4-2023 10:35 AM
End Date
19-4-2023 10:50 AM
Abstract
Danistab has demonstrated a quick molecular response and has proved itself to be useful in treating many cases of Chronic Myeloid Leukemia (CML) and Acute Lymphatic Leukemia (ALL). However, there has been no published research on how the alteration of the structure of Dansitab could increase binding affinity as well as the efficacy of its synthesis in our bodies. Using a computer aided we created novel compounds based on dasatinib and improved its ability to bind to proteins, enhancing its effectiveness, reducing needed material, and improving its ability to be synthesized. Our designed compounds included the improvement of the molecules polarity, bonding, compatibility, solubility, and toxicity. One of the most important factors that we focused on in our designs was the rate of human absorption (HIA) to see if our drug would be easily absorbed in the human body. This ultimately increased the affinity of our designed molecules with the binding site, escalating the possibility for inhibition and the efficiency in its synthesis.
Design and Synthesis of Analogs of Dasatinib as Potential Treatments for Chronic Myeloid Leukemia and Acute Lymphatic Leukemia
Danistab has demonstrated a quick molecular response and has proved itself to be useful in treating many cases of Chronic Myeloid Leukemia (CML) and Acute Lymphatic Leukemia (ALL). However, there has been no published research on how the alteration of the structure of Dansitab could increase binding affinity as well as the efficacy of its synthesis in our bodies. Using a computer aided we created novel compounds based on dasatinib and improved its ability to bind to proteins, enhancing its effectiveness, reducing needed material, and improving its ability to be synthesized. Our designed compounds included the improvement of the molecules polarity, bonding, compatibility, solubility, and toxicity. One of the most important factors that we focused on in our designs was the rate of human absorption (HIA) to see if our drug would be easily absorbed in the human body. This ultimately increased the affinity of our designed molecules with the binding site, escalating the possibility for inhibition and the efficiency in its synthesis.