Utilization of Computer-Aided Drug Design for the Treatment of Bipolar Disorder
Session Number
Project ID: MEDH 08
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
19-4-2023 10:35 AM
End Date
19-4-2023 10:50 AM
Abstract
Nearly seven million adults in the United States experience bipolar disorder. Symptoms of this mental illness include extreme mood swings rapidly ranging from depressive episodes to periods of mania. Currently, mood stabilizers such as antidepressants and antipsychotics are used for the treatment of bipolar disorder alongside therapeutic options. One such treatment is the antipsychotic risperidone and its active metabolite 9-hydroxyrisperidone which are ~88% and ~77% protein-bound in human plasma, respectively. This project's intention was to design analogs of risperidone using computer-aided drug design with a program called SeeSAR. Thus far, there have been several designed molecules that bind better to the target protein and in turn, are theoretically more effective. This would mean that the medication would more effectively bipolar disorder.
Utilization of Computer-Aided Drug Design for the Treatment of Bipolar Disorder
Nearly seven million adults in the United States experience bipolar disorder. Symptoms of this mental illness include extreme mood swings rapidly ranging from depressive episodes to periods of mania. Currently, mood stabilizers such as antidepressants and antipsychotics are used for the treatment of bipolar disorder alongside therapeutic options. One such treatment is the antipsychotic risperidone and its active metabolite 9-hydroxyrisperidone which are ~88% and ~77% protein-bound in human plasma, respectively. This project's intention was to design analogs of risperidone using computer-aided drug design with a program called SeeSAR. Thus far, there have been several designed molecules that bind better to the target protein and in turn, are theoretically more effective. This would mean that the medication would more effectively bipolar disorder.