Design and Synthesis of Potential Treatments for Leishmaniasis
Session Number
Project ID: CHEM 06
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
19-4-2023 10:50 AM
End Date
19-4-2023 11:05 AM
Abstract
Leishmaniasis is a parasitic disease found in 88 countries, a majority of which are located in the tropic or subtropics, earning it the title of a neglected tropical disease (NTD). The disease is primarily characterized by fevers, enlarged spleens, weight loss, and swollen glands. This study was done in collaboration with the Drugs for Neglected Disease Initiative (DNDi) and the University of Otago. Three analogs of DNDi’s lead compound were synthesized and purified for this study. Afterward, nuclear magnetic resonance (NMR) was completed to characterize the compounds’ structures and NMR predictors were run to confirm structures. All compounds synthesized will be sent to our collaborators for biological testing and the results will be used to design and synthesize more potent compounds in the future.
Design and Synthesis of Potential Treatments for Leishmaniasis
Leishmaniasis is a parasitic disease found in 88 countries, a majority of which are located in the tropic or subtropics, earning it the title of a neglected tropical disease (NTD). The disease is primarily characterized by fevers, enlarged spleens, weight loss, and swollen glands. This study was done in collaboration with the Drugs for Neglected Disease Initiative (DNDi) and the University of Otago. Three analogs of DNDi’s lead compound were synthesized and purified for this study. Afterward, nuclear magnetic resonance (NMR) was completed to characterize the compounds’ structures and NMR predictors were run to confirm structures. All compounds synthesized will be sent to our collaborators for biological testing and the results will be used to design and synthesize more potent compounds in the future.