Finding an Alternative to Metformin
Session Number
Project ID: CHEM 04
Advisor(s)
Dr. John Thurmond; Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
19-4-2023 10:50 AM
End Date
19-4-2023 11:05 AM
Abstract
Metformin is one of the oldest drugs that is still currently used, and it is the most prescribed drug for treating diabetes. While Metformin is incredibly inert (as a result of it being a biguanide), it does not bind to its binding site too strongly. Through my research, I have developed hundreds of alternatives to Metformin using computer aided drug design, the majority of which bind better than Metformin does. One particularly interesting result (and the molecule that binds to the site the strongest) has a strength that scales with the length of a hydrocarbon chain contained within, most likely as a result of a pocket in the binding site.
Finding an Alternative to Metformin
Metformin is one of the oldest drugs that is still currently used, and it is the most prescribed drug for treating diabetes. While Metformin is incredibly inert (as a result of it being a biguanide), it does not bind to its binding site too strongly. Through my research, I have developed hundreds of alternatives to Metformin using computer aided drug design, the majority of which bind better than Metformin does. One particularly interesting result (and the molecule that binds to the site the strongest) has a strength that scales with the length of a hydrocarbon chain contained within, most likely as a result of a pocket in the binding site.