Design and Synthesis of Potential Treatments for Leishmaniasis
Session Number
Project ID: CHEM 14
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 8:15 AM
End Date
17-4-2024 8:30 AM
Abstract
Leishmaniasis is a parasitic disease that mainly infects mammals through bites from sandflies. Not only is it primarily seen affecting people in low-income areas, but also people with other infections that debilitate the immune system, like HIV. Immunosuppressed people get infected more easily, which in turn gives the disease more hosts to spread. Medicinal treatments for Leishmaniasis are extremely lacking in efficiency and accessibility. Some treatments that have been used before to fight Leishmaniasis have been proven to be toxic to humans, overly expensive, ineffective, or take too long to begin its effect. The corresponding carboxylic acids were reacted with amine, DIPEA, and HATU solution to create three new compounds. Column chromatography was used to work up and purify the compounds. The products were then subjected to IR and NMR testing. The objective is to develop a leishmaniasis treatment that is affordable, efficient in less than ten days, and safe for people with immunosuppressive diseases like HIV.
Design and Synthesis of Potential Treatments for Leishmaniasis
Leishmaniasis is a parasitic disease that mainly infects mammals through bites from sandflies. Not only is it primarily seen affecting people in low-income areas, but also people with other infections that debilitate the immune system, like HIV. Immunosuppressed people get infected more easily, which in turn gives the disease more hosts to spread. Medicinal treatments for Leishmaniasis are extremely lacking in efficiency and accessibility. Some treatments that have been used before to fight Leishmaniasis have been proven to be toxic to humans, overly expensive, ineffective, or take too long to begin its effect. The corresponding carboxylic acids were reacted with amine, DIPEA, and HATU solution to create three new compounds. Column chromatography was used to work up and purify the compounds. The products were then subjected to IR and NMR testing. The objective is to develop a leishmaniasis treatment that is affordable, efficient in less than ten days, and safe for people with immunosuppressive diseases like HIV.