Drug Discovery on Tropical Disease
Session Number
Project ID: MEDH 50
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
17-4-2024 8:15 AM
End Date
17-4-2024 8:30 AM
Abstract
Leishmaniasis, a tropical disease, poses significant challenges due to the unreliability, toxicity, and cost of current treatments. Addressing this, a novel treatment approach is under investigation, focusing on 5-chloro-1,3-benzoxazol-2-amine, a promising compound identified through the Drugs for Neglected Diseases Initiative's Open Synthesis Network. This molecule is undergoing rigorous testing, including Proton Nuclear Magnetic Resonance and Infrared Spectroscopy, to verify its structure. To synthesize the intended molecule, the 5-chloro-1,3-benzoxazol-2-amine was reacted with one of three carboxylic acids: Fluorophenylacetic acid, p-Tolylacetic acid Methylphenylacetic acid). Both acids resulted in some mine yield; however, neither yielded enough to be considered a final product that would work.
Drug Discovery on Tropical Disease
Leishmaniasis, a tropical disease, poses significant challenges due to the unreliability, toxicity, and cost of current treatments. Addressing this, a novel treatment approach is under investigation, focusing on 5-chloro-1,3-benzoxazol-2-amine, a promising compound identified through the Drugs for Neglected Diseases Initiative's Open Synthesis Network. This molecule is undergoing rigorous testing, including Proton Nuclear Magnetic Resonance and Infrared Spectroscopy, to verify its structure. To synthesize the intended molecule, the 5-chloro-1,3-benzoxazol-2-amine was reacted with one of three carboxylic acids: Fluorophenylacetic acid, p-Tolylacetic acid Methylphenylacetic acid). Both acids resulted in some mine yield; however, neither yielded enough to be considered a final product that would work.