Synthesis of Potential Therapeutics for Mycetoma
Session Number
Project ID: CHEM 08
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 8:35 AM
End Date
17-4-2024 8:50 AM
Abstract
Mycetoma is a prevalent infectious disease commonly found in tropical regions. It has been difficult to find treatment because the current options include things such as limited therapeutic options, prolonged treatment durations, and drug resistance issues. To solve this and synthesize the final products, we added the amine (4-methylpiperidine) to the chloride (3- [chloro(4-chloro-2-fluorophenyl)methyl]pyridine) to make Compound 1. To make Compound 2 we added the amine (4-ethylpiperidine) to the chloride (3- [chloro(4-chloro-2- fluorophenyl)methyl]pyridine). For compound 3 we added the amine (piperidine) to the chloride 3-[chloro(4-chloro-2- fluorophenyl)methyl]pyridine. The compounds then went through a 48-hour reaction, were cooled, and then partitioned between dichloromethane and a saturated aqueous sodium carbonate solution. The organic phases were washed, dried, filtered, and concentrated to obtain a crude product and then purified. Compounds 1, 2, and 3 were successfully synthesized and showed promising data in our tests. Compounds 1, 2, and 3 exhibited favorable physicochemical attributes, warranting sustained inquiry for their potential role in advancing as a novel therapeutic modality for Mycetoma.
Synthesis of Potential Therapeutics for Mycetoma
Mycetoma is a prevalent infectious disease commonly found in tropical regions. It has been difficult to find treatment because the current options include things such as limited therapeutic options, prolonged treatment durations, and drug resistance issues. To solve this and synthesize the final products, we added the amine (4-methylpiperidine) to the chloride (3- [chloro(4-chloro-2-fluorophenyl)methyl]pyridine) to make Compound 1. To make Compound 2 we added the amine (4-ethylpiperidine) to the chloride (3- [chloro(4-chloro-2- fluorophenyl)methyl]pyridine). For compound 3 we added the amine (piperidine) to the chloride 3-[chloro(4-chloro-2- fluorophenyl)methyl]pyridine. The compounds then went through a 48-hour reaction, were cooled, and then partitioned between dichloromethane and a saturated aqueous sodium carbonate solution. The organic phases were washed, dried, filtered, and concentrated to obtain a crude product and then purified. Compounds 1, 2, and 3 were successfully synthesized and showed promising data in our tests. Compounds 1, 2, and 3 exhibited favorable physicochemical attributes, warranting sustained inquiry for their potential role in advancing as a novel therapeutic modality for Mycetoma.