Synthesis of Novel Medicinal Compounds Against Leishmaniasis
Session Number
Project ID: CHEM 07
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 8:55 AM
End Date
17-4-2024 9:10 AM
Abstract
Leishmaniasis is a parasitic disease primarily affecting poverty-stricken tropical and subtropical regions, including Africa, Latin America, the Middle East, and southern Asian countries. It is the second most prevalent and deadly parasitic disease after Malaria. Current treatments and therapies are becoming ineffective, causing a high demand for safe and low-cost oral treatments. A recent development for such treatment comes from a new HIT molecule, OSN Project 5 (DNDI0003202883) or 5-chloro-1,3-benzoxazol- 2-amine. Our research uses the benzoxazole chemotype to develop new medicinal compounds suitable for biological testing. Our synthesizing of compounds helps target/eliminate potential/faulty medicinal compounds that we can then communicate through our research the results for more experienced chemists to work from and help develop the steps for a global medical movement to aid against NTDs. Our collective aim is to create a low-cost, easy-to-manufacture, and effective cure for Visceral Leishmaniasis that cuts through the inequity of current treatments and is easily accessible to the globe.
Synthesis of Novel Medicinal Compounds Against Leishmaniasis
Leishmaniasis is a parasitic disease primarily affecting poverty-stricken tropical and subtropical regions, including Africa, Latin America, the Middle East, and southern Asian countries. It is the second most prevalent and deadly parasitic disease after Malaria. Current treatments and therapies are becoming ineffective, causing a high demand for safe and low-cost oral treatments. A recent development for such treatment comes from a new HIT molecule, OSN Project 5 (DNDI0003202883) or 5-chloro-1,3-benzoxazol- 2-amine. Our research uses the benzoxazole chemotype to develop new medicinal compounds suitable for biological testing. Our synthesizing of compounds helps target/eliminate potential/faulty medicinal compounds that we can then communicate through our research the results for more experienced chemists to work from and help develop the steps for a global medical movement to aid against NTDs. Our collective aim is to create a low-cost, easy-to-manufacture, and effective cure for Visceral Leishmaniasis that cuts through the inequity of current treatments and is easily accessible to the globe.