Developing Novel Therapeutics for Leishmaniasis
Session Number
Project ID: CHEM 17
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 9:20 AM
End Date
17-4-2024 9:35 AM
Abstract
Leishmaniasis is a parasitic disease endemic to tropical and subtropical regions around the world, and can cause severe harm or even death if untreated. Due to a lack of effective and affordable therapeutic methods, development of a treatment that fulfills both of these criteria is of the utmost importance. Due to the disease’s variability, many species, and treatment resistance, a potent cost-effective treatment is difficult to develop, leading to our research focus. Our experiment focused on synthesizing the analogs of the hit compound DNDI0003202883. The analogs incorporate crucial modifications around the aromatic ring, allowing the analysis of the compound’s SAR. The compounds identified in this study retained the advantageous physicochemical properties of the hit compound. These analogs add to the knowledge toward the development of a novel leishmaniasis treatment and the compound class as a whole warrants further research.
Developing Novel Therapeutics for Leishmaniasis
Leishmaniasis is a parasitic disease endemic to tropical and subtropical regions around the world, and can cause severe harm or even death if untreated. Due to a lack of effective and affordable therapeutic methods, development of a treatment that fulfills both of these criteria is of the utmost importance. Due to the disease’s variability, many species, and treatment resistance, a potent cost-effective treatment is difficult to develop, leading to our research focus. Our experiment focused on synthesizing the analogs of the hit compound DNDI0003202883. The analogs incorporate crucial modifications around the aromatic ring, allowing the analysis of the compound’s SAR. The compounds identified in this study retained the advantageous physicochemical properties of the hit compound. These analogs add to the knowledge toward the development of a novel leishmaniasis treatment and the compound class as a whole warrants further research.