Synthesis of New Compounds for Leishmaniasis Treatment
Session Number
Project ID: CHEM 11
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 9:40 AM
End Date
17-4-2024 9:55 AM
Abstract
While progress has been made in the development of treatments for tropical diseases such as malaria, there have been few advancements in the treatment of Leishmaniasis. Leishmaniasis is a parasitic disease that can lead to disfigurement of death if not treated. Current medicine is hard to access, and the treatment from these medicines is not effective enough to be taken in a few doses. Additionally, no vaccines exist for the disease. The danger this lack of treatment presents has prompted many scientists and researchers to work towards more effective treatments of the disease. This project was run to discover possible candidates for these new treatments based off of lead compound DNDI0003202833. 5-chloro-1,3-benzoxazol-2-amine was reacted with four different carboxylic acids and characterized using infrared spectroscopy. Final compounds will be sent to a collaborator's lab for biological testing.
Synthesis of New Compounds for Leishmaniasis Treatment
While progress has been made in the development of treatments for tropical diseases such as malaria, there have been few advancements in the treatment of Leishmaniasis. Leishmaniasis is a parasitic disease that can lead to disfigurement of death if not treated. Current medicine is hard to access, and the treatment from these medicines is not effective enough to be taken in a few doses. Additionally, no vaccines exist for the disease. The danger this lack of treatment presents has prompted many scientists and researchers to work towards more effective treatments of the disease. This project was run to discover possible candidates for these new treatments based off of lead compound DNDI0003202833. 5-chloro-1,3-benzoxazol-2-amine was reacted with four different carboxylic acids and characterized using infrared spectroscopy. Final compounds will be sent to a collaborator's lab for biological testing.