Synthesis of a Benzoxazole Derivative to be Used for the Treatment of Tropical Cutaneous Leishmaniasis
Session Number
Project ID: CHEM 09
Advisor(s)
Dr. John Thurmond: Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 10:00 AM
End Date
17-4-2024 10:15 AM
Abstract
Cutaneous Leishmaniasis is an infectious parasitic disease caused by the bite of infected female sandflies and characterized by disfiguring, slow healing, and re-forming skin lesions that leave lifelong scars. The goal of our effort was to synthesize derivatives of a Benzoxazole to be tested by the Drugs for Neglected Diseases Initiative (DNDi) for their effectiveness in treating cutaneous leishmaniasis. Three final compounds were synthesized from the reaction of carboxylic acids 3-chlorobenzoic acid, 3- (methylthio) benzoic acid, and 3-methoxybenzoic acid with the amine, 2-amino-5-chlorobenzoxazole.
Synthesis of a Benzoxazole Derivative to be Used for the Treatment of Tropical Cutaneous Leishmaniasis
Cutaneous Leishmaniasis is an infectious parasitic disease caused by the bite of infected female sandflies and characterized by disfiguring, slow healing, and re-forming skin lesions that leave lifelong scars. The goal of our effort was to synthesize derivatives of a Benzoxazole to be tested by the Drugs for Neglected Diseases Initiative (DNDi) for their effectiveness in treating cutaneous leishmaniasis. Three final compounds were synthesized from the reaction of carboxylic acids 3-chlorobenzoic acid, 3- (methylthio) benzoic acid, and 3-methoxybenzoic acid with the amine, 2-amino-5-chlorobenzoxazole.