Developing Novel Therapeutics for Leishmaniasis: Design and Synthesis Strategies
Session Number
CHEM 15
Advisor(s)
Dr. John Thurmond, Illinois Mathematics and Science Academy
Discipline
Chemistry
Start Date
17-4-2024 11:05 AM
End Date
17-4-2024 11:20 AM
Abstract
Leishmaniasis is a tropical disease caused by infection, primarily spread by sandflies. Current treatments are unreliable, toxic, and expensive, making them unfeasible for many. A new treatment is being researched, using 5-chloro-1,3-benzoxazol-2-amine, a promising lead amine researched by the Drugs for Neglected Diseases Initiative's Open Synthesis Network. The synthesized analogs underwent Proton Nuclear Magnetic Resonance and Infrared Spectroscopy tests to determine if the intended molecule was made. The synthesized molecules will be sent to our collaborator for biological testing. To make the intended molecules, the 5-chloro-1,3- benzoxazol-2-amine derivatives were synthesized with one of three carboxylic acids (fluorophenylacetic acid, dimethylphenylacetic acid, chlorobenzoic acid) each one done separately. The fluorophenylacetic acid analog was synthesized with the amine in two separate experiments. The first experiment seemed to yield the amine, while the second experiment showed more promising results in yielding more of the desired product.
Developing Novel Therapeutics for Leishmaniasis: Design and Synthesis Strategies
Leishmaniasis is a tropical disease caused by infection, primarily spread by sandflies. Current treatments are unreliable, toxic, and expensive, making them unfeasible for many. A new treatment is being researched, using 5-chloro-1,3-benzoxazol-2-amine, a promising lead amine researched by the Drugs for Neglected Diseases Initiative's Open Synthesis Network. The synthesized analogs underwent Proton Nuclear Magnetic Resonance and Infrared Spectroscopy tests to determine if the intended molecule was made. The synthesized molecules will be sent to our collaborator for biological testing. To make the intended molecules, the 5-chloro-1,3- benzoxazol-2-amine derivatives were synthesized with one of three carboxylic acids (fluorophenylacetic acid, dimethylphenylacetic acid, chlorobenzoic acid) each one done separately. The fluorophenylacetic acid analog was synthesized with the amine in two separate experiments. The first experiment seemed to yield the amine, while the second experiment showed more promising results in yielding more of the desired product.