Title

Diagnostic AβO-targeted probes for Alzheimer’s Disease

Authors

Nafay Abdul '20, Illinois Mathematics and Science AcademyFollow
Sophia Pribus '20, Illinois Mathematics and Science AcademyFollow

Document Type

Conference Paper/Presentation

Conference

2019 Korea Science Academy Science Fair (KSASF)

Publication Date

6-2019

Advisor(s)

Kirsten Viola, Northwestern University

William Klein, Ph.D., Northwestern University

Abstract

Aβ Oligomers (called AβOs) are small peptides that show early build-up in immunohistochemistry and immunochemistry studies, and appear before plaques in Alzheimer’s development. High levels of AβOs cause loss of memory performance and other pathological changes.Early presentation of AβOs makes them ideal for diagnostic targeting with AβO-specific antibodies Bound to magnetic nanostructures (MNSs) for MRI visibility. Further testing can determine effectiveness of future pharmaceuticals for AD therapy.

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Abdul, N., & Pribus, S. (2019). Diagnostic AβO-targeted probes for Alzheimer’s Disease.
Retrieved from: https://digitalcommons.imsa.edu/student_pr/44