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Document Type
Conference Paper/Presentation
Publication Date
10-2020
Advisor(s)
Dr. Jones Parker, PhD; Northwestern University, Feinberg School of Medicine
Abstract
Dopamine signaling is thought to alter the excitability of the striatum’s principal neurons (D1- and D2-SPNs). We used immunohistochemistry to quantify the expression of Fos, a marker of neural activity, in mice trained in a head-fixed, striatum-dependent fear conditioning task. We observed a relative increase in Fos-expressing D1- vs D2-SPNs, which may indicate how activity in these neurons facilitates motor learning. Our findings have implications for understanding disease processes that affect the dopamine system, such as Parkinson’s disease and schizophrenia.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Mu, C.,
&
Shao, E.
(2020).
Immediate Early Gene Expression in D1-SPNs and D2-SPNs During a Striatum-dependent Reinforcement Learning Task.
Retrieved from: https://digitalcommons.imsa.edu/student_pr/72